Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?
Kittel-Schneider S, Arteaga-Henriquez G, Vasquez AA, Asherson P, Banaschewski T, Brikell I, Buitelaar J, Cormand B, Faraone SV, Freitag CM, Ginsberg Y, Haavik J, Hartman CA, Kuntsi J, Larsson H, Matura S, McNeill RV, Ramos-Quiroga JA, Ribases M, Romanos M, Vainieri I, Franke B, Reif A (2022)
Publication Type: Journal article, Review article
Publication year: 2022
Journal
Book Volume: 132
Pages Range: 1157-1180
DOI: 10.1016/j.neubiorev.2021.10.035
Abstract
Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms, genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals.
Involved external institutions
Aarhus University
Denmark (DK)
Donders Institute for Brain, Cognition and Behaviour
Netherlands (NL)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
State University of New York Upstate Medical University (SUNY)
United States (USA) (US)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Karolinska Institute
Sweden (SE)
Haukeland University Hospital / Haukeland universitetssykehus
Norway (NO)
University of Groningen / Rijksuniversiteit Groningen
Netherlands (NL)
King’s College London
United Kingdom (GB)
Universitätsklinikum Würzburg
Germany (DE)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron
Spain (ES)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
Denmark (DK)
Donders Institute for Brain, Cognition and Behaviour
Netherlands (NL)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
State University of New York Upstate Medical University (SUNY)
United States (USA) (US)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Karolinska Institute
Sweden (SE)
Haukeland University Hospital / Haukeland universitetssykehus
Norway (NO)
University of Groningen / Rijksuniversiteit Groningen
Netherlands (NL)
King’s College London
United Kingdom (GB)
Universitätsklinikum Würzburg
Germany (DE)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron
Spain (ES)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
How to cite
APA:
Kittel-Schneider, S., Arteaga-Henriquez, G., Vasquez, A.A., Asherson, P., Banaschewski, T., Brikell, I.,... Reif, A. (2022). Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity? Neuroscience and Biobehavioral Reviews, 132, 1157-1180. https://doi.org/10.1016/j.neubiorev.2021.10.035
MLA:
Kittel-Schneider, Sarah, et al. "Non-mental diseases associated with ADHD across the lifespan: Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?" Neuroscience and Biobehavioral Reviews 132 (2022): 1157-1180.
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