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Multifunctional hybrid chitosan/κ-carrageenan sponges integrating engineered SBA-15@Fe3O4 composites and nano-hydroxyapatite for bone tissue engineering

Vargas-Osorio Z, García-Acevedo P, Piñeiro Y, Michálek M, Luzardo-Álvarez A, Otero-Espinar FJ, Boccaccini AR, Rivas J (2026)

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Publication Type: Journal article

Publication year: 2026

Journal

Book Volume: 353

Article Number: 151201

DOI: 10.1016/j.ijbiomac.2026.151201

Abstract

Conventional therapies often struggle to overcome key challenges associated with bone tissue disorders that demand advanced and sustained therapy solutions. This underscores the urgent need for multifunctional platforms that combine diagnostic and therapeutic functions with bioactive, degradable, and mechanically robust components. Herein, BDDE-crosslinked chitosan/κ-carrageenan sponges incorporating engineered SBA-15/Fe3O4 composites and nano-sized hydroxyapatite (nHAp) crystals were fabricated and investigated. The resulting hybrid sponges exhibited full shape recovery after mechanical compression under wet conditions and a remarkable absorption capacity without compromising their porous structure, attributed to strong structural integrity. The encapsulated SBA-15/Fe3O4 particles imparted hierarchical porosity and significant surface roughness, enabling high loading (≥150 mg/g) of simvastatin, a drug with potential to enhance bone regeneration, as well as its controlled release over extended periods ≥30 days. Additionally, these engineered composites conferred magnetic hyperthermia functionality, achieving specific absorption rates (SAR) ranging from 1.82 W·g⁻¹to 22.44 W·g⁻¹when applied a magnetic field of 28 mT at different kHz, providing them with the ability to modulate the heat response. The incorporation of nHAp into the sponge formulation enhanced both their bioactivity when tested in simulated physiological media, and cell adhesion and proliferation, as confirmed by in vitro direct and indirect contact assays. Cytocompatibility assessments using mouse macrophage (RAW 264.7), human osteosarcoma (MG-63), and preosteoblast (MC3T3-E1) cell lines demonstrated ≥80% viability across all models, revealing the highest proliferation in direct contact. These synergistic and versatile sponges hold promise for applications in bone tissue engineering.

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How to cite

APA:

Vargas-Osorio, Z., García-Acevedo, P., Piñeiro, Y., Michálek, M., Luzardo-Álvarez, A., Otero-Espinar, F.J.,... Rivas, J. (2026). Multifunctional hybrid chitosan/κ-carrageenan sponges integrating engineered SBA-15@Fe3O4 composites and nano-hydroxyapatite for bone tissue engineering. International Journal of Biological Macromolecules, 353. https://doi.org/10.1016/j.ijbiomac.2026.151201

MLA:

Vargas-Osorio, Zulema, et al. "Multifunctional hybrid chitosan/κ-carrageenan sponges integrating engineered SBA-15@Fe3O4 composites and nano-hydroxyapatite for bone tissue engineering." International Journal of Biological Macromolecules 353 (2026).

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