Different sodium concentrations of noncancerous and cancerous prostate tissue seen on MRI using an external coil.
Tan JL, Kalia V, Pautler SE, Bauman G, Gast L, Müller M, Nagel AM, Thiessen JD, Scholl TJ, Akbari A (2024)
Publication Language: English
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 1
Article Number: umae023
Journal Issue: 3
Abstract
BACKGROUND: Sodium (23Na) MRI of prostate cancer (PCa) is a novel but underdocumented technique conventionally acquired using an endorectal coil. These endorectal coils are associated with challenges (e.g., a nonuniform sensitivity profile, limited prostate coverage, patient discomfort) that could be mitigated with an external 23Na MRI coil.
PURPOSE: To quantify tissue sodium concentration (TSC) differences within the prostate of participants with PCa and healthy volunteers using an external 23Na MRI radiofrequency coil at 3 T.
MATERIALS AND METHODS: A prospective study was conducted from January 2022 to June 2024 in healthy volunteers and participants with biopsy-proven PCa. Prostate 23Na MRI was acquired on a 3-T PET/MRI scanner using a custom-built 2-loop (diameter, 18 cm) butterfly surface coil tuned for the 23Na frequency (32.6 MHz). The percent difference in TSC (ΔTSC) between prostate cancer lesions and surrounding noncancerous prostate tissue of the peripheral zone (PZ) and transition zone (TZ) was evaluated using a 1-sample t-test. TSC was compared to apparent diffusion coefficient (ADC) measurements as a clinical reference.
RESULTS: Six healthy volunteers (mean age, 54.5 years ± 12.7) and 20 participants with PCa (mean age, 70.7 years ± 8.3) were evaluated. A total of 31 lesions were detected (21 PZ, 10 TZ) across PCa participants. Compared to noncancerous prostate tissue, prostate cancer lesions had significantly lower TSC (ΔTSC, -14.1% ± 18.2, P = .0002) and ADC (ΔADC, -26.6% ± 18.7, P < .0001).
CONCLUSION: We used an external 23Na MRI coil for whole-gland comparison of TSC in PCa and noncancerous prostate tissue at 3 T. PCa lesions presented with lower TSC compared to surrounding noncancerous PZ and TZ tissue. These findings demonstrate the feasibility of an external 23Na MRI coil to quantify TSC in the prostate and offer a promising, noninvasive approach to PCa diagnosis and management.
Authors with CRIS profile
Lena Gast
Institute of Radiology
Max Müller
Institute of Radiology
Armin Michael Nagel
Professur für metabolische und funktionelle MR-Bildgebung
Involved external institutions
Canada (CA)How to cite
APA:
Tan, J.L., Kalia, V., Pautler, S.E., Bauman, G., Gast, L., Müller, M.,... Akbari, A. (2024). Different sodium concentrations of noncancerous and cancerous prostate tissue seen on MRI using an external coil. Radiology Advances, 1(3). https://doi.org/10.1093/radadv/umae023
MLA:
Tan, Josephine L., et al. "Different sodium concentrations of noncancerous and cancerous prostate tissue seen on MRI using an external coil." Radiology Advances 1.3 (2024).
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