Schöbel L, Artes J, Lorke M, Boccaccini AR (2026)
Publication Type: Journal article
Publication year: 2026
Book Volume: 12
Pages Range: 1440-1445
Journal Issue: 3
DOI: 10.1021/acsbiomaterials.5c01832
The present study introduces an injectable oxidized alginate-gelatin hydrogel system for cartilage tissue engineering, employing a combination of covalent and noncovalent cross-linking mechanisms. Specifically, the network is formed through Schiff’s Base reactions alongside enzymatic and ionic cross-linking. The hydrogels were investigated regarding their mechanical properties, swelling and degradation behavior, injectability, and cytocompatibility. The results indicated tailorable mechanical properties with an effective modulus ranging from 12 to 20 kPa, depending on the enzymatic cross-linker concentration, while demonstrating suitable injectability required for clinical applications with injection forces in the range of 3–5 N. Moreover, the syringe-mixing approach of in situ cross-linked hydrogels showed favorable cell–material interactions with chondrogenic ATDC5 cells.
APA:
Schöbel, L., Artes, J., Lorke, M., & Boccaccini, A.R. (2026). Injectable in Situ Cross-linked Oxidized Alginate-Gelatin-Based Hydrogels for Cartilage Tissue Engineering. ACS Biomaterials Science and Engineering, 12(3), 1440-1445. https://doi.org/10.1021/acsbiomaterials.5c01832
MLA:
Schöbel, Lisa, et al. "Injectable in Situ Cross-linked Oxidized Alginate-Gelatin-Based Hydrogels for Cartilage Tissue Engineering." ACS Biomaterials Science and Engineering 12.3 (2026): 1440-1445.
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