A bio-nanocomposite hydrogel based on β-cyclodextrin and straw mushroom (Volvariella volvacea) soluble polysaccharide for the delivery of capsaicin and alleviation effect on type II diabetes mellitus
Hu W, Zeng Z, Gou L, Luo X, Luo Y, Shaker M, Zhou N (2026)
Publication Type: Journal article
Publication year: 2026
Journal
Book Volume: 381
Article Number: 124857
DOI: 10.1016/j.carbpol.2025.124857
Abstract
Type II diabetes mellitus (T2DM) remains a global health challenge, necessitating innovative drug delivery strategies to improve treatment efficacy. Capsaicin (CAP), a bioactive compound with promising antidiabetic potential, is limited by its poor solubility and bioavailability. To address these limitations, a hydrogel nanocomposite system (HGNCs) based on β-cyclodextrin (β-CD) and soluble polysaccharides from Volvariella volvacea (VVPS) was developed for the efficient CAP delivery. We further assessed its remission effect on T2DM. The results showed that CAP was successfully encapsulated within the hydrophobic cavity of the HGNCS, forming core-shell nanoparticles with average particle size of 145.73 ± 22.81 nm, with the encapsulation efficiency and drug loading reached 63.27 % and 13.22 %, respectively. In vivo pharmacodynamic studies demonstrated that the HGNCs/CAP system extended CAP's peak time to 60 min through a sustained-release effect and significantly increased its bioavailability to 11.79 %, nearly three times higher than that of free CAP. In animal experiments with diabetic rats, HGNCs/CAP effectively reduced fasting blood glucose and insulin resistance, enhanced oral glucose tolerance, and promoted insulin secretion. Moreover, HGNCs/CAP significantly improved dyslipidemia, lowered blood urea nitrogen and uric acid levels, and repaired the glomerular basement membrane thickening and the reduction in islet β-cell loss. Single-cell transcriptome analysis further reavealed that CAP inhibits the fibrotic process and alleviates the inflammatory environment by regulating fatty acid metabolism, mitochondrial function and inflammation-related pathways in renal proximal convoluted tubule cells. This study presents a novel biocompatible vector for CAP delivery system and confirms its therapeutic potential in T2DM through multi-dimensional mechanisms, offering a new pathway for diabetes treatment.
Authors with CRIS profile
Involved external institutions
Chongqing Academy of Agricultural Sciences / 重庆市农业科学院
China (CN)
Chongqing Academy of Chinese Materia Medica / 重庆市中药研究院
China (CN)
First Affiliated Hospital of Chongqing Medical University / 重庆医科大学附属第一医院
China (CN)
China (CN)
Chongqing Academy of Chinese Materia Medica / 重庆市中药研究院
China (CN)
First Affiliated Hospital of Chongqing Medical University / 重庆医科大学附属第一医院
China (CN)
How to cite
APA:
Hu, W., Zeng, Z., Gou, L., Luo, X., Luo, Y., Shaker, M., & Zhou, N. (2026). A bio-nanocomposite hydrogel based on β-cyclodextrin and straw mushroom (Volvariella volvacea) soluble polysaccharide for the delivery of capsaicin and alleviation effect on type II diabetes mellitus. Carbohydrate Polymers, 381. https://doi.org/10.1016/j.carbpol.2025.124857
MLA:
Hu, Wei, et al. "A bio-nanocomposite hydrogel based on β-cyclodextrin and straw mushroom (Volvariella volvacea) soluble polysaccharide for the delivery of capsaicin and alleviation effect on type II diabetes mellitus." Carbohydrate Polymers 381 (2026).
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