Seitz S, Rauh M, Glöckler M, Cesnjevar R, Dittrich S, Koch A (2013)
Publication Type: Journal article
Publication year: 2013
Book Volume: 143
Article Number: w13744
QUESTIONS UNDER STUDY: To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinaseassociated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS: Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive patients with congenital heart defects aged 3 days to 30 years after admission to the intensive care unit, 2 and 6 hours after the end of cardiopulmonary bypass. Biomarker levels were compared to perioperative data retrospectively. Acute kidney injury was defined according to the paediatric-modified RIFLE classification. RESULTS: According to the paediatric-modified RIFLE criteria 53% of patients developed evidence of acute kidney injury. Serum Cystatin C concentrations were strongly correlated with severity of acute kidney injury. Optimal sensitivity of 80% and specificity of 66% for the prediction of acute kidney injury occurred at a cut-off value of 0.995 mg/l, 2 hours after the end of cardiopulmonary bypass. The 2 hour urine NGAL concentration was significantly correlated to the duration of cardiopulmonary bypass, time of aortic cross clamping, and serum lactate concentration. Moreover a significant correlation was found between urine NGAL and both length of hospital stay and mechanical ventilation. CONCLUSIONS: In patients after congenital heart surgery, urine NGAL indicates the damaging force of cardiopulmonary bypass and serum Cystatin C is a valuable predictive biomarker for resulting acute kidney injury.
APA:
Seitz, S., Rauh, M., Glöckler, M., Cesnjevar, R., Dittrich, S., & Koch, A. (2013). Cystatin C and neutrophil gelatinase-associated lipocalin: Biomarkers for acute kidney injury after congenital heart surgery. Swiss Medical Weekly, 143. https://doi.org/10.4414/smw.2013.13744
MLA:
Seitz, Sigurd, et al. "Cystatin C and neutrophil gelatinase-associated lipocalin: Biomarkers for acute kidney injury after congenital heart surgery." Swiss Medical Weekly 143 (2013).
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