ISCEV extended protocol for the photoreceptor directed ERG using full-field silent substitution stimuli identification

Kremers J, Barboni MT, Zele AJ, Feigl B, McAnany JJ, Robson AG, Nagy BV, Parry N, Mahroo OA, Huchzermeyer C (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Documenta Ophthalmologica Springer Verlag (Germany)

DOI: 10.1007/s10633-026-10087-w

Abstract

The International Society for Clinical Electrophysiology of Vision (ISCEV) Standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the full-field ERG Standard, namely the ERG responses to silent substitution stimuli that are directed at the response modulation of single photoreceptor types. The method can be used to detect selective defects in distinct photoreceptor types and post-receptoral retinal pathways. This document, based on existing literature, provides protocols for recording and analyzing the responses to a single class of photoreceptor directed stimuli. For each photoreceptor type (rods, L-, M- and S-cones), optimal luminance conditions and temporal frequencies for Ganzfeld recordings are provided. The exact stimulus conditions depend on the spectral properties of the stimulator. An accompanying technical report describes an app that is meant to provide support in calculating stimuli for individual stimulators.

Authors with CRIS profile

Jan Kremers Professur für Experimentelle Augenheilkunde Cord Huchzermeyer Department of Ophthalmology

Involved external institutions

Semmelweis University / Semmelweis Egyetem HU Hungary (HU) Queensland University of Technology (QUT) AU Australia (AU) University of Illinois at Chicago US United States (USA) (US) Budapest University of Technology and Economics (BME) / Budapesti Műszaki és Gazdaságtudományi Egyetem HU Hungary (HU) Manchester Royal Eye Hospital GB United Kingdom (GB) Moorfields Eye Hospital NHS Foundation Trust GB United Kingdom (GB)

How to cite

APA:

Kremers, J., Barboni, M.T., Zele, A.J., Feigl, B., McAnany, J.J., Robson, A.G.,... Huchzermeyer, C. (2026). ISCEV extended protocol for the photoreceptor directed ERG using full-field silent substitution stimuli identification. Documenta Ophthalmologica. https://doi.org/10.1007/s10633-026-10087-w

MLA:

Kremers, Jan, et al. "ISCEV extended protocol for the photoreceptor directed ERG using full-field silent substitution stimuli identification." Documenta Ophthalmologica (2026).

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