Advances in the construction of boryl cyclobutanes
Das KK, Dey S (2026)
Publication Type: Journal article, Review article
Publication year: 2026
Journal
DOI: 10.1039/d6qo00008h
Abstract
Boryl-substituted cyclobutanes have emerged as valuable building blocks that merge the structural rigidity and strain-enabled reactivity of four-membered rings with the versatile synthetic utility of organoboron chemistry. Here, the recent advances in the synthesis of boryl-substituted cyclobutanes, a class of strained, sp3-rich building blocks that combine the structural rigidity of cyclobutanes with the exceptional versatility of organoboron chemistry, have been summarized. Emphasis is placed on strategies that exploit boronate complex reactivity and 1,2-migration processes to overcome the inherent challenges associated with four-membered ring formation. Thermal, photochemical, and transition-metal-catalysed approaches are discussed, highlighting how strain-release, radical polar crossover, and σ-bond activation enable efficient and stereocontrolled cyclobutane construction. Key mechanistic insights that govern selectivity and reactivity also have been outlined across diverse platforms.
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Germany (DE)How to cite
APA:
Das, K.K., & Dey, S. (2026). Advances in the construction of boryl cyclobutanes. Organic Chemistry Frontiers. https://doi.org/10.1039/d6qo00008h
MLA:
Das, Kanak Kanti, and Sutapa Dey. "Advances in the construction of boryl cyclobutanes." Organic Chemistry Frontiers (2026).
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