Successful treatment of severe retroauricular pyoderma gangrenosum with upadacitinib in a patient with Crohn’s disease and a history of cerebral venous sinus thrombosis

Fousekis F, Ronicke M, Sollfrank L, Rech J, Berking C, Neurath MF, Sticherling M, Atreya R (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Therapeutic Advances in Gastroenterology SAGE Publications

Book Volume: 19

Abstract

Pyoderma gangrenosum (PG) is an immune-mediated skin condition that is commonly associated with inflammatory bowel diseases (IBD). Its diagnosis and management are often challenging due to the heterogeneity of the clinical presentation and the need for an individualized therapeutic approach. We present the case of a 19-year-old Caucasian male with Crohn’s disease, who received therapy with a biological agent and developed severe PG in the retroauricular region following mastoidectomy for mastoiditis, which was complicated by cerebral venous sinus thrombosis. The diagnosis of PG was made with the help of the PARACELSUS-score based on lesion characteristics, histology, the patient’s IBD history, and lack of response to antibiotics. Treatment with upadacitinib, a selective Janus kinase 1 inhibitor, was initiated after resolution of the previous thrombotic event. The patient responded rapidly to therapy, with a notable reduction of the local inflammatory activity and wound size, and ultimately complete healing. Anticoagulation therapy did not need to be continued during treatment. The patient has been on upadacitinib for 25 months to date without adverse events or recurrence of thrombosis. This case highlights upadacitinib as a promising and safe treatment option for PG, even in patients with Crohn’s disease and a history of thrombotic events after careful benefit–risk assessment.

Authors with CRIS profile

Moritz Ronicke Department of Dermatology Lukas Sollfrank Department of Dermatology Jürgen Rech Department of Medicine 3 – Rheumatology and Immunology Carola Berking Lehrstuhl für Haut- und Geschlechtskrankheiten Michael Sticherling Department of Dermatology Raja Atreya Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

How to cite

APA:

Fousekis, F., Ronicke, M., Sollfrank, L., Rech, J., Berking, C., Neurath, M.F.,... Atreya, R. (2026). Successful treatment of severe retroauricular pyoderma gangrenosum with upadacitinib in a patient with Crohn’s disease and a history of cerebral venous sinus thrombosis. Therapeutic Advances in Gastroenterology, 19. https://doi.org/10.1177/17562848261424321

MLA:

Fousekis, Fotios, et al. "Successful treatment of severe retroauricular pyoderma gangrenosum with upadacitinib in a patient with Crohn’s disease and a history of cerebral venous sinus thrombosis." Therapeutic Advances in Gastroenterology 19 (2026).

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