Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial Protection, and Functional Skin Regeneration
Fan Z, Li M, Cai K, Xie Z, Lu B, Zhang M, Zhang Y, Wang J, Gu C, Zheng K, Chen T (2026)
Publication Type: Journal article
Publication year: 2026
Journal
Abstract
Rapid hemostasis with functional skin regeneration remains a major challenge in wound care. We engineered a flexible composite sponge by reinforcing recombinant human-like collagen (RHC) with copper-doped bioactive glass fibers (CuBGF). The CuBGF-RHC sponges exhibited a porous, highly hydrophilic, and mechanically robust architecture. In vitro, they enhanced fibroblast proliferation to ∼200% of control, accelerated wound closure to 98.7 ± 0.9% within 48 h, reduced intracellular reactive oxygen species, and suppressed pro-inflammatory macrophage polarization from 70.2% to 11.9%. Strong antibacterial activity was observed, with HCuBGF-RHC nearly eliminating Staphylococcus aureus and Escherichia coli colonies. Hemostatic assays confirmed accelerated coagulation, with clotting times reduced to 6.7 ± 0.4 min versus >10 min for gelatin sponge, and platelet adhesion increased to 41.9 ± 2.5%. In rat femoral vein bleeding models, HCuBGF-RHC reduced hemostasis time to 198.3 ± 33.3 s and blood loss to 1.33 ± 0.32 g. In full-thickness skin wounds, it achieved >93% closure by day 14, enhanced type III collagen remodeling, and restored adnexal structures. Transcriptomic analysis revealed regulation of extracellular matrix, angiogenesis, and inflammatory pathways. These findings demonstrate that CuBGF-RHC sponges integrate structural and biochemical cues to achieve both rapid hemostasis and functional skin regeneration, underscoring their translational potential in wound management.
Authors with CRIS profile
Involved external institutions
Zhengzhou Central Hospital
China (CN)
Nanjing Medical University / 南京医科大学
China (CN)
Zhengzhou University / 郑州大学
China (CN)
China (CN)
Nanjing Medical University / 南京医科大学
China (CN)
Zhengzhou University / 郑州大学
China (CN)
How to cite
APA:
Fan, Z., Li, M., Cai, K., Xie, Z., Lu, B., Zhang, M.,... Chen, T. (2026). Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial Protection, and Functional Skin Regeneration. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.202504908
MLA:
Fan, Zhe, et al. "Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial Protection, and Functional Skin Regeneration." Advanced Healthcare Materials (2026).
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