Immunohistochemical labeling of carbonic anhydrase isoenzymes in labial glands of infants

Stoeckelhuber M, Wolff KD, Kesting MR, Loeffelbein DJ, Schmitz C, Ritschl LM (2026)

Publication Type: Journal article, Review article

Publication year: 2026

Journal

Biotechnic & Histochemistry Informa Healthcare

DOI: 10.1080/10520295.2026.2618820

Abstract

In salivary glands, the concurrent availability of HCO3− is required for normal mucus release that is guaranteed by the carbonic anhydrases in this area. Due to lack of detailed carbonic anhydrase data in minor salivary glands, we identified various carbonic anhydrases (CA) in the human labial glands of infants in this study. Specifically, the CA isoenzymes II, III, IV, VI, VII, and XII were investigated in secretory and ductal epithelial cells. CA II was detected in serous glandular cells and sporadically in ductal cells, CA III in myoepithelial cells and skeletal muscle cells, CA IV in ductal cells, endothelial cells, erythrocytes, and skeletal muscle. The first immunohistochemical analysis of CA VII in salivary glands resulted in a positive reaction in serous glandular cells and ductal cells, as well as in skeletal muscle and endothelial cells. CA XII was sporadically localized at the basolateral membrane of ductal cells and in serous glandular cells. Mucous endpieces were negative in all carbonic anhydrases tested. Knowledge of carbonic anhydrases distribution in healthy tissues supports their assessment as biomarkers for cancer diagnosis, prevention, and therapy.

Authors with CRIS profile

Marco Rainer Kesting Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie (MKG)

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Klinikum der Universität München (LMU Klinikum) DE Germany (DE)

How to cite

APA:

Stoeckelhuber, M., Wolff, K.D., Kesting, M.R., Loeffelbein, D.J., Schmitz, C., & Ritschl, L.M. (2026). Immunohistochemical labeling of carbonic anhydrase isoenzymes in labial glands of infants. Biotechnic & Histochemistry. https://doi.org/10.1080/10520295.2026.2618820

MLA:

Stoeckelhuber, Mechthild, et al. "Immunohistochemical labeling of carbonic anhydrase isoenzymes in labial glands of infants." Biotechnic & Histochemistry (2026).

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