Lymphopenia and CD4+/CD8+ Cell Reduction under Fumaric Acid Esters
Sondermann W, Rompoti N, Leister L, Huptas L, Klode J, Dissemond J, Körber A (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 233
Pages Range: 295-302
Journal Issue: 4
DOI: 10.1159/000478903
Abstract
Background: Fumaric acid esters (FAEs) are a broadly used therapy option for patients suffering from moderate-to-severe plaque psoriasis. Various studies in psoriasis have already shown peripheral blood lymphopenia during oral FAE therapy. Smaller studies also documented a reduction of CD4+ and CD8+ cell counts. Up to now, there are few case reports on opportunistic infections under FAE therapy - all of them associated with lymphopenia. Objective: To examine the influence of FAEs on white blood cells with special regard to leukocytes, lymphocytes, and CD4+ and CD8+ cells during psoriasis therapy. Patients and Methods: A cohort of 105 patients with diagnosed moderate-to-severe chronic plaque psoriasis was enrolled in this single-centre observational trial. For a cohort of 36 patients, T-cell subset analyses were performed. Results: Of the total, 65 patients were male (61.9%) and 40 (38.1%) female; the mean age was 43.3 years (range 16-73 years). The median lymphocyte count was significantly reduced by about 35.8% after the first 6 months of therapy. When assessing the lymphocyte count nadir over the whole period observed, 46.7% of the patients developed lymphopenia. Severe lymphopenia (<500/μL) was documented in 11.4% of the patients. The CD4+ and CD8+ cell counts were significantly reduced by about 30.2 and 45.3%, respectively. Conclusion: To the best of our knowledge this is the largest clinical investigation analysing prospectively CD4+ and CD8+ cell counts in psoriasis patients receiving FAEs. We suggest periodic monitoring of absolute lymphocyte counts as well as the establishment of the determination of T-cell subsets prior to and during therapy.
Involved external institutions
Germany (DE)How to cite
APA:
Sondermann, W., Rompoti, N., Leister, L., Huptas, L., Klode, J., Dissemond, J., & Körber, A. (2018). Lymphopenia and CD4+/CD8+ Cell Reduction under Fumaric Acid Esters. Dermatology, 233(4), 295-302. https://doi.org/10.1159/000478903
MLA:
Sondermann, Wiebke, et al. "Lymphopenia and CD4+/CD8+ Cell Reduction under Fumaric Acid Esters." Dermatology 233.4 (2018): 295-302.
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