JAG1 of all trades, master of CKD? The role of JAG1 in autosomal dominant tubulointerstitial kidney disease

Wiesener M, Olinger E (2026)

Publication Type: Journal article

Publication year: 2026

Journal

Kidney International Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 109

Pages Range: 262-265

Journal Issue: 2

DOI: 10.1016/j.kint.2025.11.006

Abstract

The current study by Menguy et al. describes JAG1 as a novel candidate gene for the spectrum of autosomal dominant tubulointerstitial kidney disease. Patients have been shown to develop fibrosis and chronic kidney disease, when distinct pathogenic germline variants occur in JAG1. Interestingly, genetic alterations in the Jagged1/Notch2 pathway can cause the variable appearance of Alagille syndrome, which may also occur in the very same families. Haploinsufficiency is the likely pathomechanism, but future work will need to define the underlying mechanisms.

Authors with CRIS profile

Michael Wiesener Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Cliniques universitaires Saint-Luc (CHU St-Luc) BE Belgium (BE)

How to cite

APA:

Wiesener, M., & Olinger, E. (2026). JAG1 of all trades, master of CKD? The role of JAG1 in autosomal dominant tubulointerstitial kidney disease. Kidney International, 109(2), 262-265. https://doi.org/10.1016/j.kint.2025.11.006

MLA:

Wiesener, Michael, and Eric Olinger. "JAG1 of all trades, master of CKD? The role of JAG1 in autosomal dominant tubulointerstitial kidney disease." Kidney International 109.2 (2026): 262-265.

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