Norfloxacin La(III)-based complex: Synthesis, characterization, and DNA-binding studies

Shaban SY, El-Kemary MA, Samir G, El-Baradei H, Puchta R (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Journal of Coordination Chemistry Taylor & Francis

Book Volume: 68

Pages Range: 3247-3258

Journal Issue: 17-18

DOI: 10.1080/00958972.2015.1065320

Abstract

A La(III) complex, [LaIIICl2(NOR)2]Cl (2), containing norfloxacin (NOR) (1), a synthetic fluoroquinolone antibacterial agent, has been synthesized and characterized by elemental analysis, IR, UV-vis spectra and 1H NMR spectroscopy, and molar conductance measurements. The interaction between 2 and CT-DNA was investigated by steady-state absorption and fluorescence techniques in different pH media, and showed that 2 could bind to CT-DNA presumably via non-intercalative mode and the La(III) complex showed moderate ability to bind CT-DNA compared to other La(III) complexes. The binding site number n, and apparent binding constant KA, corresponding thermodynamic parameters ΔG#, ΔH#, ΔS# at different temperatures were calculated. The binding constant (KA) values are 0.23 ± 0.05, 0.56 ± 0.05, and 0.18 ± 0.08 × 105 L mol-1 for pH 4, 7, and 11, respectively. It was also found that the fluorescence quenching mechanism of CT-DNA by La(III) complex was a static quenching process.

Authors with CRIS profile

Ralph Puchta Lehrstuhl für Anorganische und Metallorganische Chemie

How to cite

APA:

Shaban, S.Y., El-Kemary, M.A., Samir, G., El-Baradei, H., & Puchta, R. (2015). Norfloxacin La(III)-based complex: Synthesis, characterization, and DNA-binding studies. Journal of Coordination Chemistry, 68(17-18), 3247-3258. https://doi.org/10.1080/00958972.2015.1065320

MLA:

Shaban, Shaban Y., et al. "Norfloxacin La(III)-based complex: Synthesis, characterization, and DNA-binding studies." Journal of Coordination Chemistry 68.17-18 (2015): 3247-3258.

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