A “turn-on” chemodosimeter for detection of Cu2+in living cells

Körber M, Attia D, Masson E, Mokhir A (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Dalton Transactions Royal Society of Chemistry

Book Volume: 54

DOI: 10.1039/d5dt02331a

Abstract

We synthesized an analogue of rhodamine B hydrazide via alkylation with butyl bromide. The resulting reagent, BuCh, exhibits optimal lipophilicity, maintaining both aqueous solubility and efficient cell membrane permeability. BuCh itself is weakly fluorescent, but in the presence of Cu2+it undergoes hydrolysis to release strongly fluorescent rhodamine B. We demonstrated that BuCh is well suited for monitoring chelatable intracellular Cu2+ions in mammalian cells.

Authors with CRIS profile

Marlies Rippl Lehrstuhl für Organische Chemie II Dina Attia Professur für Organische Chemie Elisabeth Masson Professur für Organische Chemie Andriy Mokhir Professur für Organische Chemie

How to cite

APA:

Körber, M., Attia, D., Masson, E., & Mokhir, A. (2025). A “turn-on” chemodosimeter for detection of Cu2+in living cells. Dalton Transactions, 54. https://doi.org/10.1039/d5dt02331a

MLA:

Körber, Marlies, et al. "A “turn-on” chemodosimeter for detection of Cu2+in living cells." Dalton Transactions 54 (2025).

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