Donor-derived PLA2R-positive membranous nephropathy after post-mortal kidney transplantation
Baarz BR, Jochims J, Unterwalder N, Amann KU, Eckardt KU, Choi M (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 18
Article Number: sfaf321
Journal Issue: 11
DOI: 10.1093/ckj/sfaf321
Abstract
Donor-derived glomerular diseases after organ transplantation are rare and may be challenging to diagnose. We report two kidney transplant recipients from a deceased donor with previously undiagnosed phospholipase A2 receptor (PLA2R)-positive membranous nephropathy (MN). Recipient 1 experienced delayed graft function with gross albuminuria; biopsy showed PLA2R-positive MN. Recipient 2 had immediate graft function. In both patients anti-PLA2R sera were negative, while retrospective donor testing confirmed an anti-PLA2R titer, suggesting donor-derived idiopathic MN. Follow-up under standard immunosuppression showed improving creatinine and partial remission of albuminuria in Recipient 1, and stable function with modest, transient albuminuria in Recipient 2. Thus, kidneys from donors with MN can yield acceptable outcomes.
Authors with CRIS profile
Involved external institutions
Charité - Universitätsmedizin Berlin
Germany (DE)
Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim)
Germany (DE)
Germany (DE)
Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim)
Germany (DE)
How to cite
APA:
Baarz, B.R., Jochims, J., Unterwalder, N., Amann, K.U., Eckardt, K.U., & Choi, M. (2025). Donor-derived PLA2R-positive membranous nephropathy after post-mortal kidney transplantation. Clinical Kidney Journal, 18(11). https://doi.org/10.1093/ckj/sfaf321
MLA:
Baarz, Bastian Robinson, et al. "Donor-derived PLA2R-positive membranous nephropathy after post-mortal kidney transplantation." Clinical Kidney Journal 18.11 (2025).
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