Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

Frischknecht R, Heine M, Perrais D, Seidenbecher CI, Choquet D, Gundelfinger ED (2009)

Publication Type: Journal article

Publication year: 2009

Journal

Nature Neuroscience Nature Publishing Group

Book Volume: 12

Pages Range: 897-904

Journal Issue: 7

DOI: 10.1038/nn.2338

Abstract

Many synapses in the mature CNS are wrapped by a dense extracellular matrix (ECM). Using single-particle tracking and fluorescence recovery after photobleaching, we found that this net-like ECM formed surface compartments on rat primary neurons that acted as lateral diffusion barriers for AMPA-type glutamate receptors. Enzymatic removal of the ECM increased extrasynaptic receptor diffusion and the exchange of synaptic AMPA receptors. Whole-cell patch-clamp recording revealed an increased paired-pulse ratio as a functional consequence of ECM removal. These results suggest that the surface compartments formed by the ECM hinder lateral diffusion of AMPA receptors and may therefore modulate short-term synaptic plasticity. © 2009 Nature America, Inc. All rights reserved.

Involved external institutions

Leibniz-Institut für Neurobiologie (LIN) DE Germany (DE) Université de Bordeaux FR France (FR)

How to cite

APA:

Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C.I., Choquet, D., & Gundelfinger, E.D. (2009). Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Nature Neuroscience, 12(7), 897-904. https://doi.org/10.1038/nn.2338

MLA:

Frischknecht, Renato, et al. "Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity." Nature Neuroscience 12.7 (2009): 897-904.

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