Extracellular matrix and synaptic functions

Dityatev A, Frischknecht R, Seidenbecher CI (2006)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2006

Journal

Results and Problems in Cell Differentiation Springer Verlag

Edited Volumes: Cell Communication in Nervous and Immune System

Series: Results and Problems in Cell Differentiation

Book Volume: 43

Pages Range: 69-97

DOI: 10.1007/400_025

Abstract

Comprehensive analysis of neuromuscular junction formation and recent data on synaptogenesis and long-term potentiation in the central nervous system revealed a number of extracellular matrix (ECM) molecules regulating different aspects of synaptic differentiation and function. The emerging mechanisms comprise interactions of ECM components with their cell surface receptors coupled to tyrosine kinase activities (agrin, integrin ligands, and reelin) and interactions with ion channels and transmitter receptors (Narp, tenascin-R and tenascin-C). These interactions may shape synaptic transmission and plasticity of excitatory synapses either via regulation of Ca2+ entry and postsynaptic expression of transmitter receptors or via control of GABAergic inhibition. The ECM molecules, derived from both neurons and glial cells and secreted into the extracellular space in an activity-dependent manner, may also shape synaptic plasticity through setting diffusion constraints for neurotransmitters, trophic factors and ions. © 2006 Springer-Verlag Berlin Heidelberg.

Authors with CRIS profile

Renato Frischknecht

Involved external institutions

Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Leibniz-Institut für Neurobiologie (LIN) DE Germany (DE)

How to cite

APA:

Dityatev, A., Frischknecht, R., & Seidenbecher, C.I. (2006). Extracellular matrix and synaptic functions. In Eckhart Gundelfinger, Constanze Seidenbecher, Bukhart Schraven (Eds.), Cell Communication in Nervous and Immune System. (pp. 69-97).

MLA:

Dityatev, Alexander, Renato Frischknecht, and Constanze I. Seidenbecher. "Extracellular matrix and synaptic functions." Cell Communication in Nervous and Immune System. Ed. Eckhart Gundelfinger, Constanze Seidenbecher, Bukhart Schraven, 2006. 69-97.

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