EndoCompass project: Research roadmap for pituitary and neuroendocrine tumor endocrinology

Castano JP, Dattani MT, Grozinsky-Glasberg S, Karavitaki N, Pavel ME, Andoniadou C, Alexandraki K, Capatina C, Cerbone M, Ferone D, Gan HW, Hofland J, Hofland LJ, Ibanez-Costa A, Ilie MD, Isidori AM, Korbonits M, Kos-Kudła B, Maghnie M, Mantovani G, Marazuela M, Raverot G, Scarpa A, Schilbach K, Theodoropoulou M, Van Santen HM, Zatelli MC (2025)

Publication Type: Journal article, Review article

Publication year: 2025

Journal

Book Volume: 193

Pages Range: ii84-ii96

Journal Issue: 2

DOI: 10.1093/ejendo/lvaf035

Abstract

Background Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in pituitary and neuroendocrine tumor endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results Research priorities encompass congenital and acquired disorders, tumor development and progression, and neuroendocrine neoplasms. Key areas include genetic/epigenetic factors, tumor microenvironment, personalized treatment approaches, developing preclinical models, and implementing artificial intelligence. Special emphasis is placed on aggressive tumors, hypothalamic syndromes, and establishing pan-European biobanks and databases. Conclusions This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into pituitary-neuroendocrine disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health

Authors with CRIS profile

Involved external institutions

University of Verona / Università degli Studi di Verona Italy (IT) Klinikum der Universität München (LMU Klinikum) Germany (DE) Wilhelmina Kinderziekenhuis Netherlands (NL) Università degli Studi di Ferrara Italy (IT) Great Ormond Street Hospital (GOSH) United Kingdom (GB) University of Genova / Università degli Studi di Genova Italy (IT) Erasmus University Medical Center (MC) Netherlands (NL) University of Cordoba / Universidad de Córdoba (UCO) Spain (ES) Centre de recherche en cancérologie France (FR) University College London (UCL) United Kingdom (GB) Hadassah Medical Center / מרכז רפואי הדסה‎‎ Israel (IL) University of Birmingham United Kingdom (GB) Universitätsklinikum Carl Gustav Carus Dresden Germany (DE) Aretaeio Private Hospital Greece (GR) Carol Davila University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie „Carol Davila” (UMF București) Romania (RO) Università degli studi "La Sapienza" Italy (IT) Queen Mary University of London United Kingdom (GB) Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach (SUM) Poland (PL) Istituto Giannina Gaslini Italy (IT) Università degli studi di Milano Italy (IT) Universidad Autónoma de Madrid (UAM) Spain (ES) Hospices Civils de Lyon (CHU) France (FR)

How to cite

APA:

Castano, J.P., Dattani, M.T., Grozinsky-Glasberg, S., Karavitaki, N., Pavel, M.E., Andoniadou, C.,... Zatelli, M.C. (2025). EndoCompass project: Research roadmap for pituitary and neuroendocrine tumor endocrinology. European Journal of Endocrinology, 193(2), ii84-ii96. https://doi.org/10.1093/ejendo/lvaf035

MLA:

Castano, Justo P., et al. "EndoCompass project: Research roadmap for pituitary and neuroendocrine tumor endocrinology." European Journal of Endocrinology 193.2 (2025): ii84-ii96.

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