Human brain slice cultures: translational applications and ethical considerations
Joseph K, Vasilikos I, Grauvogel J, Shah MJ, Reinacher PC, Nakagawa JM, Häussler U, Straehle J, Neidert NN, Fistouris P, Schneider M, Sloan SA, Weiss T, Coenen VA, Schnell O, Vlachos A, Prinz M, Hofmann UG, Beck J, Kellmeyer P, Ravi VM (2025)
Publication Language: English
Publication Type: Journal article, Review article
Publication year: 2025
Journal
Book Volume: 8
Article Number: e202403160
Journal Issue: 12
Abstract
Human organotypic brain slice cultures have emerged as a pivotal tool to study the complexities of the human brain. Human organotypic brain slice cultures preserve the structural integrity, cellular diversity, and vascular networks of living brain tissue, maintaining in vivo characteristics. This advancement enables accurate temporal modeling of neurological diseases and facilitates precise experimental manipulations, accelerating therapeutic development. However, their use raises important ethical and philosophical considerations, including issues of donor consent and the potential for neural activity that prompts questions about consciousness. This study outlines these emerging concerns, emphasizing the need for guidelines that balance scientific innovation with ethical responsibility, particularly in relation to donor consent, transparency, and long-term use of living human tissue.
Authors with CRIS profile
Involved external institutions
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Emory University
United States (USA) (US)
Universitätsspital Zürich (USZ)
Switzerland (CH)
Universitätsklinikum Freiburg
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Germany (DE)
Emory University
United States (USA) (US)
Universitätsspital Zürich (USZ)
Switzerland (CH)
Universitätsklinikum Freiburg
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
How to cite
APA:
Joseph, K., Vasilikos, I., Grauvogel, J., Shah, M.J., Reinacher, P.C., Nakagawa, J.M.,... Ravi, V.M. (2025). Human brain slice cultures: translational applications and ethical considerations. Life Science Alliance, 8(12). https://doi.org/10.26508/lsa.202403160
MLA:
Joseph, Kevin, et al. "Human brain slice cultures: translational applications and ethical considerations." Life Science Alliance 8.12 (2025).
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