Synthesis and evaluation of mesoporous cobalt-doped bioactive glass nanospheres loaded with curcumin

Coco AM, Campos FA, Martins T, Barrioni BR, Gastelois PL, Soares DC, Houmard M, Boccaccini AR, Nunes EH (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Ceramics International Elsevier

DOI: 10.1016/j.ceramint.2025.10.029

Abstract

This study focused on preparing mesoporous bioactive glass (BG) nanospheres, which are recognized for their versatility and broad biomedical applications, with an emphasis on tailoring their properties for the potential treatment of chronic skin wounds. To improve the functionality of BG, cobalt (Co) was introduced as a network-modifying cation and curcumin (Cur) was loaded onto BG nanospheres. Co is known to mimic hypoxic conditions, thereby stimulating angiogenesis and promoting wound repair. Cur is well known for its wound-healing properties and plays a key role in modulating multiple steps of the healing process, thereby contributing to accelerated tissue regeneration. The incorporation of Co induced the formation of non-bridging oxygen groups and Si-O-Co bonds, which increased the specific surface area and pore volume of BG. Conversely, Cur loading resulted in a decrease in the specific surface area, probably due to the deposition of Cur within the glass matrix pores. This study highlights the synergistic potential of BG particles loaded with Co and Cur for advancing wound healing applications.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universidade Federal de Minas Gerais (UFMG) BR Brazil (BR) Federal University of Lavras / Universidade Federal de Lavras (UFLA) BR Brazil (BR) Nuclear Technology Development Center / Centro de Desenvolvimento da Tecnologia Nuclear (CDTN) BR Brazil (BR) Federal University of Itajubá / Universidade Federal de Itajubá BR Brazil (BR)

How to cite

APA:

Coco, A.M., Campos, F.A., Martins, T., Barrioni, B.R., Gastelois, P.L., Soares, D.C.,... Nunes, E.H. (2025). Synthesis and evaluation of mesoporous cobalt-doped bioactive glass nanospheres loaded with curcumin. Ceramics International. https://doi.org/10.1016/j.ceramint.2025.10.029

MLA:

Coco, Amanda M.A., et al. "Synthesis and evaluation of mesoporous cobalt-doped bioactive glass nanospheres loaded with curcumin." Ceramics International (2025).

BibTeX: Download