Long-lived adult-born hippocampal neurons promote successful cognitive aging
Blin N, Charrier V, Farrugia F, Palhol J, Presset A, Cartier E, Oliet S, Pacary E, Koehl M, Lie DC, Masachs N, Abrous DN (2025)
Publication Type: Journal article
Publication year: 2025
Journal
DOI: 10.1038/s41380-025-03286-5
Abstract
Aging is commonly associated with a decline in memory abilities, yet some individuals remain resilient to such changes. Memory processing has been shown to rely on adult neurogenesis, a form of hippocampal plasticity, but whether the integration and role of long-lived adult-born neurons (ABNs) generated during early adult life also contribute to cognitive resilience and to such inter-individual differences remain unknown. Using a pseudo-longitudinal approach in rats characterized as resilient or vulnerable to cognitive aging, we examined the survival, senescence, morphology, glutamatergic connectivity, and mitochondrial health of ABNs. To achieve this, we combined approaches based on thymidine analogues and retroviral labeling using Moloney murine leukemia viruses. While ABNs survival, entry into senescence and dendritic gross morphology did not differ between resilient and vulnerable rats, resilient animals exhibited preserved glutamatergic synaptic input and maintained mitochondrial homeostasis in the proximal dendrites of ABNs. Interestingly, bypassing this reduction in glutamatergic inputs in vulnerable rats through direct optogenetic stimulation was sufficient to rescue their memory retrieval abilities, indicating that ABNs themselves remain intrinsically functional despite reduced input. Overall, our data indicate that maintaining long-lived ABNs within the neuronal network is essential for successful cognitive aging, highlighting their potential as a therapeutic target for restoring cognitive functions in old age.
Authors with CRIS profile
Involved external institutions
France (FR)How to cite
APA:
Blin, N., Charrier, V., Farrugia, F., Palhol, J., Presset, A., Cartier, E.,... Abrous, D.N. (2025). Long-lived adult-born hippocampal neurons promote successful cognitive aging. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-03286-5
MLA:
Blin, Nicolas, et al. "Long-lived adult-born hippocampal neurons promote successful cognitive aging." Molecular Psychiatry (2025).
BibTeX: Download