Endoscopic peroral jejunal fecal microbiota transplantation
Link A, Lachmund T, Schulz C, Weigt J, Malfertheiner P (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 48
Pages Range: 1336-1339
Journal Issue: 11
DOI: 10.1016/j.dld.2016.08.110
Abstract
Background Fecal microbiota transplantation (FMT) is a valuable treatment modality for recurrent Clostridium difficile (C. difficile) colitis. Multiple questions including the best delivery route and volume remain unanswered. Here, we report a case series of high-volume FMT using endoscopic jejunal application route. Methods In prospective observational study, FMT was performed using fresh specimen from healthy unrelated donors to the patients with recurrent or refractory C. difficile colitis. Selection of the route was based on the patient's preferences. Specimens of at least 50 g were dissolved in 500 ml of electrolyte solution and administered using endoscope directly in jejunum. Results All procedures led to cure of C. difficile colitis. With exception of one case the procedure was well tolerated. In two cases, we observed FMT-reflux into the stomach despite deep jejunal application and in single case the FMT-reflux led to tracheal aspiration and severe pneumonia. Conclusions High-volume FMT via endoscopic jejunal route is an effective treatment option that is well tolerated and easy to perform. Nevertheless, aspiration is potential life-threatening event that needs to be kept in mind during the FMT-procedure.
Involved external institutions
Germany (DE)How to cite
APA:
Link, A., Lachmund, T., Schulz, C., Weigt, J., & Malfertheiner, P. (2016). Endoscopic peroral jejunal fecal microbiota transplantation. Digestive and Liver Disease, 48(11), 1336-1339. https://doi.org/10.1016/j.dld.2016.08.110
MLA:
Link, Alexander, et al. "Endoscopic peroral jejunal fecal microbiota transplantation." Digestive and Liver Disease 48.11 (2016): 1336-1339.
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