Helicobacter pylori eradication therapy is not associated with the onset of inflammatory bowel diseases. A case-control study

Rosania R, Arnim UV, Link A, Rajilic-Stojanovic M, Franck C, Canbay A, Malfertheiner P, Venerito M (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Journal of Gastrointestinal and Liver Diseases Romanian Society of Gastroenterology and Hepatology

Book Volume: 27

Pages Range: 119-125

Journal Issue: 2

DOI: 10.15403/jgld.2014.1121.272.hpy

Abstract

Background & Aims: A negative association between H. pylori and inflammatory bowel disease (IBD) has been previously reported. There were also case reports suggesting a new onset of IBD 6-12 months after H. pylori eradication therapy. In a case-control study we investigated whether previous H. pylori eradication therapy was associated with the risk of developing IBD. Methods: IBD outpatients with both Crohn´s disease (CD) and ulcerative colitis (UC) were enrolled. Age-and sex-matched blood donors served as controls in a 1:2 fashion. Information on demographics, medical history, previous H. pylori infection and eradication therapy was recorded. Serum samples for H. pylori serology testing (anti-H. pylori-IgG and anti-CagA-IgG) were obtained. Controls that received H. pylori eradication therapy during the 12 months previous to enrollment were excluded. Results: Overall, 127 IBD patients (CD N= 90; UC N= 37) and 254 controls were enrolled. The prevalence of H. pylori infection (positive H. pylori serology and/or previous eradication) in IBD patients and controls was 11% and 23%, respectively (OR 0.4, 95% CI 0.21-0.74, p<0.003). Four patients (3%) developed IBD (3 MC and 1 CU) after receiving successful H. pylori eradication (latency 6-12 months). The rate of previous H. pylori eradication therapy in patents who successively developed IBD was lower but not statistically different from that observed in the control group (OR 0.43, 95% CI 0.14-1.29, p=0.16). Conclusions: In our study previous H. pylori eradication therapy was not associated with the onset of IBD. Whether in a subgroup of patients, H. pylori eradication therapy may trigger a latent IBD, cannot be excluded.

Involved external institutions

Otto-von-Guericke-Universität Magdeburg DE Germany (DE) University of Belgrade / Универзитет у Београду RS Serbia (RS)

How to cite

APA:

Rosania, R., Arnim, U.V., Link, A., Rajilic-Stojanovic, M., Franck, C., Canbay, A.,... Venerito, M. (2018). Helicobacter pylori eradication therapy is not associated with the onset of inflammatory bowel diseases. A case-control study. Journal of Gastrointestinal and Liver Diseases, 27(2), 119-125. https://doi.org/10.15403/jgld.2014.1121.272.hpy

MLA:

Rosania, Rosa, et al. "Helicobacter pylori eradication therapy is not associated with the onset of inflammatory bowel diseases. A case-control study." Journal of Gastrointestinal and Liver Diseases 27.2 (2018): 119-125.

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