MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives
Link A, Kupcinskas J (2018)
Publication Type: Journal article, Review article
Publication year: 2018
Journal
Book Volume: 24
Pages Range: 3313-3329
Journal Issue: 30
Abstract
Non-invasive diagnostic biomarkers may contribute to an early identification of gastric cancer (GC) and improve the clinical management. Unfortunately, no sensitive and specific screening biomarkers are available yet and the currently available approaches are limited by the nature of the disease. GC is a heterogenic disease with various distinct genetic and epigenetic events that occur during the multifactorial cascade of carcinogenesis. MicroRNAs (miRNAs) are commonly deregulated in gastric mucosa during the Helicobacter pylori infection and in stepwise manner from chronic gastritis, through preneoplastic conditions such as atrophic gastritis and intestinal metaplasia, to early dysplasia and invasive cancer. Identification of miRNAs in blood in 2008 led to a great interest on miRNA-based diagnostic, prognostic biomarkers in GC. In this review, we provide the most recent systematic review on the existing studies related to miRNAs as diagnostic biomarkers for GC. Here, we systematically evaluate 75 studies related to differential expression of circulating miRNAs in GC patients and provide novel view on various heterogenic aspects of the existing data and summarize the methodological differences. Finally, we highlight several important aspects crucial to improve the future translational and clinical research in the field.
Involved external institutions
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Lithuanian University of Health Sciences / Lietuvos sveikatos mokslų universitetas (LSMU)
Lithuania (LT)
Germany (DE)
Lithuanian University of Health Sciences / Lietuvos sveikatos mokslų universitetas (LSMU)
Lithuania (LT)
How to cite
APA:
Link, A., & Kupcinskas, J. (2018). MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives. World Journal of Gastroenterology, 24(30), 3313-3329. https://doi.org/10.3748/wjg.v24.i30.3313
MLA:
Link, Alexander, and Juozas Kupcinskas. "MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives." World Journal of Gastroenterology 24.30 (2018): 3313-3329.
BibTeX: Download