Feasibility of combined screening for upper gastrointestinal adenocarcinoma risk by serology and Cytosponge testing: The SUGAR study
Xu Y, Miremadi A, Link A, Malfertheiner P, Fitzgerald RC, Bornschein J (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 72
Pages Range: 825-829
Journal Issue: 12
DOI: 10.1136/jclinpath-2019-205700
Abstract
Aims Aim was to assess the feasibility of serum markers to identify individuals at risk for gastro-oesophageal adenocarcinoma to reduce the number of individuals requiring invasive assessment by endoscopy. Methods Blood samples from 56 patients with Barrett's oesophagus and 202 non-Barrett controls who previously took part in a trial assessing the accuracy of the Cytosponge for Barrett's oesophagus were assessed for serum pepsinogen (PG) 1 and 2, gastrin-17, trefoil factor 3 (TFF3) and Helicobacter pylori infection. Results PG1 was pathological (<50 ng/mL) in 26 patients (10.1%), none of whom had Barrett's oesophagus (p<0.001). Smoking and drinking had no influence on these results. Pathological PG1 was associated with stomach pain (p=0.029), disruption of sleep (p=0.027) and disruption of diet by symptoms (p=0.019). Serum TFF3 was not associated with any clinical parameter. Conclusions Assessment of serum PG1 could be combined with a test for Barrett's oesophagus to identify additional patients requiring endoscopy.
Involved external institutions
University of Cambridge
United Kingdom (GB)
Cambridge University Hospitals
United Kingdom (GB)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
United Kingdom (GB)
Cambridge University Hospitals
United Kingdom (GB)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
How to cite
APA:
Xu, Y., Miremadi, A., Link, A., Malfertheiner, P., Fitzgerald, R.C., & Bornschein, J. (2019). Feasibility of combined screening for upper gastrointestinal adenocarcinoma risk by serology and Cytosponge testing: The SUGAR study. Journal of Clinical Pathology, 72(12), 825-829. https://doi.org/10.1136/jclinpath-2019-205700
MLA:
Xu, Yiwang, et al. "Feasibility of combined screening for upper gastrointestinal adenocarcinoma risk by serology and Cytosponge testing: The SUGAR study." Journal of Clinical Pathology 72.12 (2019): 825-829.
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