A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group

Keller JJ, Ooijevaar RE, Hvas CL, Terveer EM, Lieberknecht SC, Högenauer C, Arkkila P, Sokol H, Gridnyev O, Mégraud F, Kump PK, Nakov R, Goldenberg SD, Satokari R, Tkatch S, Sanguinetti M, Cammarota G, Dorofeev A, Gubska O, Ianiro G, Mattila E, Arasaradnam RP, Sarin SK, Sood A, Putignani L, Alric L, Baunwall SM, Kupcinskas J, Link A, Goorhuis AG, Verspaget HW, Ponsioen C, Hold GL, Tilg H, Kassam Z, Kuijper EJ, Gasbarrini A, Mulder CJ, Williams HR, Vehreschild MJ (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 9

Pages Range: 229-247

Journal Issue: 2

DOI: 10.1177/2050640620967898

Abstract

Background: Faecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of faeces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council. Objective: Several European and international consensus statements concerning faecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document. Methods: Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about faecal microbiota transplantation. Results: A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening. Conclusion: The implementation of faecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor faeces preparations for patients.

Authors with CRIS profile

Involved external institutions

Bogomolets National Medical University / Национальный медицинский университет имени А. А. Богомольца Ukraine (UA) Fondazione Policlinico Universitario Agostino Gemelli IRCCS Italy (IT) Medizinische Universität Graz Austria (AT) Université Fédérale de Toulouse Midi-Pyrénées France (FR) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra Netherlands (NL) Leiden University Medical Center Netherlands (NL) Finch Therapeutics Group, Inc. United States (USA) (US) National Academy of Medical Sciences of Ukraine (NAMS) / NAMS Ukraine Ukraine (UA) Université de Bordeaux France (FR) Institute of Liver and Biliary Sciences (ILBS) India (IN) Dayanand Medical College & Hospital India (IN) Medizinische Universität Innsbruck Austria (AT) Guy's and St Thomas' (NHS Foundation Trust) United Kingdom (GB) Aleksandrovska University Hospital / университетска болница "Александровска" Bulgaria (BG) University Hospitals Coventry and Warwickshire United Kingdom (GB) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) Ukrainian Scientific and Practical Center for Endocrine Surgery / Український науково-практичний центр ендокринної хірургії Ukraine (UA) University of New South Wales (UNSW) Australia (AU) Lithuanian University of Health Sciences / Lietuvos sveikatos mokslų universitetas (LSMU) Lithuania (LT) Shupyk National Healthcare University of Ukraine / Національний університет охорони здоров'я України імені П. Л. Шупика Ukraine (UA) Hôpital Saint-Antoine France (FR) Ospedale Pediatrico Bambino Gesu Italy (IT) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) University of Turku / Turun yliopisto Finland (FI) Otto-von-Guericke-Universität Magdeburg Germany (DE) Helsinki University Central Hospital (HUCH) / Helsingin seudun yliopistollinen keskussairaala (HYKS) Finland (FI)

How to cite

APA:

Keller, J.J., Ooijevaar, R.E., Hvas, C.L., Terveer, E.M., Lieberknecht, S.C., Högenauer, C.,... Vehreschild, M.J. (2021). A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group. United European Gastroenterology Journal, 9(2), 229-247. https://doi.org/10.1177/2050640620967898

MLA:

Keller, Josbert J., et al. "A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group." United European Gastroenterology Journal 9.2 (2021): 229-247.

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