Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease
Lemmer P, Manka P, Best J, Kahraman A, Kälsch J, Vilchez-vargas R, Link A, Chiang H, Gerken G, Canbay A, Bechmann LP, Sydor S (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 11
Article Number: 890
Journal Issue: 3
DOI: 10.3390/jcm11030890
Abstract
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have emerged as leading causes of chronic liver diseases worldwide. ALD and NAFLD share several pathophysiological patterns as well as histological features, while clinically, they are distinguished by the amount of alcohol consumed daily. However, NAFLD coexists with moderate alcohol consumption in a growing proportion of the population. Here, we investigated the effects of moderate alcohol consumption on liver injury, lipid metabolism, and gut microbiota in 30 NAFLD-patients. We anonymously assessed drinking habits, applying the AUDIT- and CAGE-questionnaires and compared subgroups of abstainers vs. low to harmful alcohol consumers (AUDIT) and Cage 0–1 vs. Cage 2–4. Patients who did not drink any alcohol had lower levels of γGT, ALT, triglycerides, and total cholesterol. While the abundance of Bacteroidaceae, Bifidobacteriaceae, Streptococcaceae, and Ruminococcaceae was higher in the low to harmful alcohol drinking cohort, the abundance of Rikenellaceae was higher in the abstainers. Our study suggests that even moderate alcohol consumption has an impact on the liver and lipid metabolism, as well as on the composition of gut microbiota.
Involved external institutions
Universitätsklinikum Essen
Germany (DE)
Universitätsklinikum Knappschaftskrankenhaus Bochum
Germany (DE)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Germany (DE)
Universitätsklinikum Knappschaftskrankenhaus Bochum
Germany (DE)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
How to cite
APA:
Lemmer, P., Manka, P., Best, J., Kahraman, A., Kälsch, J., Vilchez-vargas, R.,... Sydor, S. (2022). Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease. Journal of Clinical Medicine, 11(3). https://doi.org/10.3390/jcm11030890
MLA:
Lemmer, Peter, et al. "Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease." Journal of Clinical Medicine 11.3 (2022).
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