Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults
Xu H, Jurado-Fasoli L, Ortiz-Alvarez L, Osuna-Prieto FJ, Kohler I, Di X, Vilchez-Vargas R, Link A, Plaza-Díaz J, Gil A, Rensen PC, Ruiz JR, Martinez-Tellez B (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 14
Article Number: 4991
Journal Issue: 23
DOI: 10.3390/nu14234991
Abstract
Pre-clinical studies suggest that circulating oxylipins, i.e., the oxidation products of polyunsaturated fatty acids (PUFAs), modulate gut microbiota composition in mice, but there is no information available in humans. Therefore, this study aimed to investigate the relationship between omega-3 and omega-6 derived oxylipins plasma levels and fecal microbiota composition in a cohort of young adults. 80 young adults (74% women; 21.9 ± 2.2 years old) were included in this cross-sectional study. Plasma levels of oxylipins were measured using liquid chromatography-tandem mass spectrometry. Fecal microbiota composition was analyzed by V3-V4 16S rRNA gene sequencing. We observed that plasma levels of omega-3 derived oxylipins were positively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho ≥ 0.415, p ≤ 0.009) and negatively associated with the relative abundance of Sutterella genus (Proteobacteria phylum; rho ≥ −0.270, p ≤ 0.041), respectively. Moreover, plasma levels of omega-6 derived oxylipins were negatively associated with the relative abundance of Acidaminococcus and Phascolarctobacterium genera (Firmicutes phylum; all rho ≥ −0.263, p ≤ 0.024), as well as Sutterella, Succinivibrio, and Gemmiger genera (Proteobacteria phylum; all rho ≥ −0.263, p ≤ 0.024). Lastly, the ratio between omega-6 and omega-3 oxylipins plasma levels was negatively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho = −0.334, p = 0.004) and Butyricimonas genus (Bacteroidetes phylum; rho = −0.292, p = 0.014). In conclusion, our results show that the plasma levels of omega-3 and omega-6 derived oxylipins are associated with the relative abundance of specific fecal bacteria genera.
Authors with CRIS profile
Involved external institutions
Vrije Universiteit Amsterdam (VU) / University Amsterdam
Netherlands (NL)
Universidad de Granada
Spain (ES)
Leiden University Medical Center
Netherlands (NL)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Leiden University
Netherlands (NL)
Netherlands (NL)
Universidad de Granada
Spain (ES)
Leiden University Medical Center
Netherlands (NL)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Leiden University
Netherlands (NL)
How to cite
APA:
Xu, H., Jurado-Fasoli, L., Ortiz-Alvarez, L., Osuna-Prieto, F.J., Kohler, I., Di, X.,... Martinez-Tellez, B. (2022). Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults. Nutrients, 14(23). https://doi.org/10.3390/nu14234991
MLA:
Xu, Huiwen, et al. "Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults." Nutrients 14.23 (2022).
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