Timing of radiotherapy following breast-conserving surgery: Outcome of 1393 patients at a single institution
Corradini S, Niemoeller OM, Niyazi M, Manapov F, Haerting M, Harbeck N, Belka C, Kahlert S (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 190
Pages Range: 352-357
Journal Issue: 4
DOI: 10.1007/s00066-013-0540-x
Abstract
Background. The role of postoperative radiotherapy in breast-conserving therapy is undisputed. However, optimal timing of adjuvant radiotherapy is an issue of ongoing debate. This retrospective clinical cohort study was performed to investigate the impact of a delay in surgery-radiotherapy intervals on local control and overall survival. Patients and methods. Data from an unselected cohort of 1393 patients treated at a single institution over a 17-year period (1990-2006) were analyzed. Patients were assigned to two groups (CT+/CT-) according to chemotherapy status. A delay in the initiation of radiotherapy was defined as > 7 weeks (CT- group) and > 24 weeks (CT+ group). Results. The 10-year regional recurrence-free survival for the CT- and CT+ groups were 95.6 and 86.0 %, respectively. A significant increase in the median surgery-radiotherapy interval was observed over time (CT- patients: median of 5 weeks in 1990-1992 to a median of 6 weeks in 2005-2006; CT+ patients: median of 5 weeks in 1990-1992 to a median of 21 weeks in 2005-2006). There was no association between a delay in radiotherapy and an increased local recurrence rate (CT- group: p = 0.990 for intervals 0-6 weeks vs. ≥ 7 weeks; CT+ group: p = 0.644 for intervals 0-15 weeks vs. ≥ 24 weeks) or decreased overall survival (CT- group: p = 0.386 for intervals 0-6 weeks vs. ≥ 7 weeks; CT+ group: p = 0.305 for intervals 0-15 weeks vs. ≥ 24 weeks). Conclusion. In the present cohort, a delay of radiotherapy was not associated with decreased local control or overall survival in the two groups (CT-/CT+). However, in the absence of randomized evidence, delays in the initiation of radiotherapy should be avoided. © 2014 Springer-Verlag.
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APA:
Corradini, S., Niemoeller, O.M., Niyazi, M., Manapov, F., Haerting, M., Harbeck, N.,... Kahlert, S. (2014). Timing of radiotherapy following breast-conserving surgery: Outcome of 1393 patients at a single institution. Strahlentherapie und Onkologie, 190(4), 352-357. https://doi.org/10.1007/s00066-013-0540-x
MLA:
Corradini, S., et al. "Timing of radiotherapy following breast-conserving surgery: Outcome of 1393 patients at a single institution." Strahlentherapie und Onkologie 190.4 (2014): 352-357.
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