Dose variability in different lymph node levels during locoregional breast cancer irradiation: the impact of deep-inspiration breath hold Dosisvariabilität verschiedener Lymphknotenstationen während der lokoregionalen Bestrahlung bei Mammakarzinom: Einfluss des Luftanhaltens in tiefer Inspiration
Pazos M, Fiorentino A, Gaasch A, Schönecker S, Reitz D, Heinz C, Niyazi M, Duma MN, Alongi F, Belka C, Corradini S (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 195
Pages Range: 13-20
Journal Issue: 1
DOI: 10.1007/s00066-018-1350-y
Abstract
Purpose: Aim of the present analysis was to evaluate the movement and dose variability of the different lymph node levels of node-positive breast cancer patients during adjuvant radiotherapy (RT) with regional nodal irradiation (RNI) in deep-inspiration breath hold (DIBH). Methods: Thirty-five consecutive node-positive breast cancer patients treated from October 2016 to February 2018 receiving postoperative RT of the breast or chest wall including RNI of the supra-/infraclavicular lymph node levels (corresponding to levels IV, III, Rotter LN (interpectoral), and some parts of level II) were analyzed. To evaluate the lymph node level movement, a center of volume (COV) was obtained for each lymph node level for free-breathing (FB) and DIBH plans. Geometric shifts and dose differences between FB and DIBH were analyzed. Results: A significant movement of the COV in anterior (y) and cranial (z) dimensions was observed for lymph node levels I–II and Rotter lymph nodes (p < 0.001) due to DIBH. Only minor changes in the lateral dimension (x axis) were observed, without reaching significance for levels III, IV, and internal mammary. There was a significant difference in the mean dose of level I (DIBH vs. FB: 38.2 Gy/41.3 Gy, p < 0.001) and level II (DIBH vs. FB: 45.9 Gy/47.2 Gy, p < 0.001), while there was no significant difference in level III (p = 0.298), level IV (p = 0.476), or internal mammary nodes (p = 0.471). Conclusion: A significant movement of the axillary lymph node levels was observed during DIBH in anterior and cranial directions for node-positive breast cancer patients in comparison to FB. The movement leads to a significant dose reduction in level I and level II.
Involved external institutions
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
Ospedale Sacro Cuore Don Calabria
Italy (IT)
Klinikum rechts der Isar
Germany (DE)
Germany (DE)
Ospedale Sacro Cuore Don Calabria
Italy (IT)
Klinikum rechts der Isar
Germany (DE)
How to cite
APA:
Pazos, M., Fiorentino, A., Gaasch, A., Schönecker, S., Reitz, D., Heinz, C.,... Corradini, S. (2019). Dose variability in different lymph node levels during locoregional breast cancer irradiation: the impact of deep-inspiration breath hold Dosisvariabilität verschiedener Lymphknotenstationen während der lokoregionalen Bestrahlung bei Mammakarzinom: Einfluss des Luftanhaltens in tiefer Inspiration. Strahlentherapie und Onkologie, 195(1), 13-20. https://doi.org/10.1007/s00066-018-1350-y
MLA:
Pazos, Montserrat, et al. "Dose variability in different lymph node levels during locoregional breast cancer irradiation: the impact of deep-inspiration breath hold Dosisvariabilität verschiedener Lymphknotenstationen während der lokoregionalen Bestrahlung bei Mammakarzinom: Einfluss des Luftanhaltens in tiefer Inspiration." Strahlentherapie und Onkologie 195.1 (2019): 13-20.
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