Stereotactic body radiotherapy of central lung malignancies using a simultaneous integrated protection approach: A prospective observational study Stereotaktische Bestrahlung zentraler Lungenmaligome mit simultan integrierter Protektion (SIP) von Risikoorganen: Eine prospektive Beobachtungsstudie
Mazzola R, Ruggieri R, Figlia V, Rigo M, Giaj Levra N, Ricchetti F, Nicosia L, Corradini S, Alongi F (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 195
Pages Range: 719-724
Journal Issue: 8
DOI: 10.1007/s00066-018-01419-0
Abstract
Aim: It is recognized that stereotactic body radiotherapy (SBRT) for centrally located lung metastases is affected by higher rates of severe toxicity. In the present study, we report the clinical outcomes following a novel intensity-modulated radiotherapy prescription dose, termed simultaneous integrated protection (SIP), for nearby organs at risk (OARs). Materials and methods: The prescribed total doses of SBRT were 70 Gy in 10 fractions and 60 Gy in 8 fractions. For ultra-centrally located lesions, a dose of 60 Gy in 10 fractions was delivered. The main planning instructions were: (1) to remain within the limits of the given dose constraints for an OAR; (2) to make use of the maximum possible dose to the OARs to minimize dose inhomogeneity for the Planning Target Volume (PTV). SBRT-related toxicity was prospectively assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) v4.0. The primary clinical endpoint was the SBRT-related toxicity. Secondary endpoint was local control. Results: Forty patients affected by a single central malignancy were analyzed. The median follow-up was 20 months (range, 6–58 months). Acute and late clinical pulmonary toxicity ≥grade 2 was recorded in 2 out of 40 patients (5%) and 3 out of 40 patients (7%), respectively. No patient experienced cardiac toxicity. No narrowing or stenosis of any airway or vessel was registered. One-year local control rate was 91%. The median time to local progression was 13 months (range, 6–46 months). Conclusion: SBRT using a PTV-SIP approach for single central lung metastases achieved low SBRT-related toxicity with acceptable local control.
Involved external institutions
Italy (IT)
Germany (DE)How to cite
APA:
Mazzola, R., Ruggieri, R., Figlia, V., Rigo, M., Giaj Levra, N., Ricchetti, F.,... Alongi, F. (2019). Stereotactic body radiotherapy of central lung malignancies using a simultaneous integrated protection approach: A prospective observational study Stereotaktische Bestrahlung zentraler Lungenmaligome mit simultan integrierter Protektion (SIP) von Risikoorganen: Eine prospektive Beobachtungsstudie. Strahlentherapie und Onkologie, 195(8), 719-724. https://doi.org/10.1007/s00066-018-01419-0
MLA:
Mazzola, Rosario, et al. "Stereotactic body radiotherapy of central lung malignancies using a simultaneous integrated protection approach: A prospective observational study Stereotaktische Bestrahlung zentraler Lungenmaligome mit simultan integrierter Protektion (SIP) von Risikoorganen: Eine prospektive Beobachtungsstudie." Strahlentherapie und Onkologie 195.8 (2019): 719-724.
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