Stability and reproducibility of 6013 deep inspiration breath-holds in left-sided breast cancer
Reitz D, Walter F, Schönecker S, Freislederer P, Pazos M, Niyazi M, Landry G, Alongi F, Bölke E, Matuschek C, Reiner M, Belka C, Corradini S (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 15
Article Number: 121
Journal Issue: 1
DOI: 10.1186/s13014-020-01572-w
Abstract
Purpose: Patients with left-sided breast cancer frequently receive deep inspiration breath-hold (DIBH) radiotherapy to reduce the risk of cardiac side effects. The aim of the present study was to analyze intra-breath-hold stability and inter-fraction breath-hold reproducibility in clinical practice. Material and methods: Overall, we analyzed 103 patients receiving left-sided breast cancer radiotherapy using a surface-guided DIBH technique. During each treatment session the vertical motion of the patient was continuously measured by a surface guided radiation therapy (SGRT) system and automated gating control (beam on/off) was performed using an audio-visual patient feedback system. Dose delivery was automatically triggered when the tracking point was within a predefined gating window. Intra-breath-hold stability and inter-fraction reproducibility across all fractions of the entire treatment course were analyzed per patient. Results: In the present series, 6013 breath-holds during beam-on time were analyzed. The mean amplitude of the gating window from the baseline breathing curve (maximum expiration during free breathing) was 15.8 mm (95%-confidence interval: [8.5-30.6] mm) and had a width of 3.5 mm (95%-CI: [2-4.3] mm). As a measure of intra-breath-hold stability, the median standard deviation of the breath-hold level during DIBH was 0.3 mm (95%-CI: [0.1-0.9] mm). Similarly, the median absolute intra-breath-hold linear amplitude deviation was 0.4 mm (95%-CI: [0.01-2.1] mm). Reproducibility testing showed good inter-fractional reliability, as the maximum difference in the breathing amplitudes in all patients and all fractions were 1.3 mm on average (95%-CI: [0.5-2.6] mm). Conclusion: The clinical integration of an optical surface scanner enables a stable and reliable DIBH treatment delivery during SGRT for left-sided breast cancer in clinical routine.
Involved external institutions
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
Ospedale Sacro Cuore Don Calabria
Italy (IT)
Universitätsklinikum Düsseldorf
Germany (DE)
Germany (DE)
Ospedale Sacro Cuore Don Calabria
Italy (IT)
Universitätsklinikum Düsseldorf
Germany (DE)
How to cite
APA:
Reitz, D., Walter, F., Schönecker, S., Freislederer, P., Pazos, M., Niyazi, M.,... Corradini, S. (2020). Stability and reproducibility of 6013 deep inspiration breath-holds in left-sided breast cancer. Radiation Oncology, 15(1). https://doi.org/10.1186/s13014-020-01572-w
MLA:
Reitz, D., et al. "Stability and reproducibility of 6013 deep inspiration breath-holds in left-sided breast cancer." Radiation Oncology 15.1 (2020).
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