The role of radiotherapy in patients with solid tumours after solid organ transplantation: a systematic review
Mazzola R, Cuccia F, Bertani A, Tubin S, Conaldi PG, Corradini S, Tolia M, Guba M, Alongi F (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 22
Pages Range: e93-e104
Journal Issue: 3
DOI: 10.1016/S1470-2045(20)30590-8
Abstract
For patients diagnosed with cancer who have previously received an organ transplant, radiotherapy represents a challenging clinical scenario without well established care algorithms. Immunosuppressive therapy can be a cause for concern among clinicians treating this category of patients. Potential immune modulation following irradiation could affect recipient organ tolerance and the outcomes of the transplantation itself. The main aim of this systematic review was to define the safety and effectiveness of radiotherapy in patients diagnosed with cancer who have previously received an organ transplant. We searched PubMed and Embase for articles published between Jan 1, 1995, and April 30, 2020 for studies in patients who had undergone radiotherapy for post-transplantation malignancies. The Review is framed by the PICO (population, intervention, control, and outcomes) criteria, and primarily focuses on modern treatment techniques.
Involved external institutions
Ospedale Sacro Cuore Don Calabria
Italy (IT)
Mediterranean Institute for Transplantation and Advanced Specialized Therapies / Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)
Italy (IT)
EBG MedAustron GmbH
Austria (AT)
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
University of Crete / Πανεπιστήμιο Κρήτης
Greece (GR)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Italy (IT)
Mediterranean Institute for Transplantation and Advanced Specialized Therapies / Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)
Italy (IT)
EBG MedAustron GmbH
Austria (AT)
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
University of Crete / Πανεπιστήμιο Κρήτης
Greece (GR)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
How to cite
APA:
Mazzola, R., Cuccia, F., Bertani, A., Tubin, S., Conaldi, P.G., Corradini, S.,... Alongi, F. (2021). The role of radiotherapy in patients with solid tumours after solid organ transplantation: a systematic review. Lancet Oncology, 22(3), e93-e104. https://doi.org/10.1016/S1470-2045(20)30590-8
MLA:
Mazzola, Rosario, et al. "The role of radiotherapy in patients with solid tumours after solid organ transplantation: a systematic review." Lancet Oncology 22.3 (2021): e93-e104.
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