Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer

Beyer S, Wehrmann M, Meister S, Trillsch F, Ganster F, Schmoeckel E, Corradini S, Mahner S, Jeschke U, Kessler M, Burges A, Kolben T (2024)

Publication Type: Journal article

Publication year: 2024

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 25

Article Number: 6907

Journal Issue: 13

DOI: 10.3390/ijms25136907

Abstract

Endometrial cancer (EC) is a common gynecological cancer worldwide. Treatment has been improved in recent years; however, in advanced stages, therapeutic options are still limited. The expression of galectins is increased in several tumor types and that they are involved in important cell processes. Large studies on endometrial cancer are still pending; Specimens of 225 patients with EC were immunohistochemically stained with antibodies for Gal-8 and Gal-9. Expression was correlated with histopathological variables. The cytosolic expression of both galectins is associated with grading and survival. Cytosolic Galectin-8 expression is a positive prognostic factor for overall survival (OS) and progression-free survival (PFS), while nuclear Gal-8 expression correlates only to OS. The cytosolic presence of Galectin-9 is correlated with a better prognosis regarding OS. Our results suggest that expression of both galectins is associated with OS and PFS in EC. Further studies are needed to understand the underlying molecular mechanisms.

Involved external institutions

Klinikum der Universität München (LMU Klinikum) DE Germany (DE) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Beyer, S., Wehrmann, M., Meister, S., Trillsch, F., Ganster, F., Schmoeckel, E.,... Kolben, T. (2024). Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer. International Journal of Molecular Sciences, 25(13). https://doi.org/10.3390/ijms25136907

MLA:

Beyer, Susanne, et al. "Expression of Intracellular Galectin-8 and -9 in Endometrial Cancer." International Journal of Molecular Sciences 25.13 (2024).

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