Multimodal treatment options for oligometastatic colorectal cancer Multimodale Therapiemöglichkeiten beim oligometastasierten kolorektalen Karzinom
Schwenk L, Rauchfuss F, Caglayan L, Gkika E, Corradini S, Ernst T, Settmacher U (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 31
Pages Range: 452-460
Journal Issue: 5
DOI: 10.1007/s00761-025-01694-4
Abstract
Background: Colorectal cancer is one of the most common malignancies worldwide. A significant proportion of patients develop liver metastases during disease progression. Objective: The aim of this study is to present the current surgical and pharmacological treatment options as well as local ablative radiotherapy techniques for oligometastatic colorectal cancer. Results and conclusion: Surgery remains the primary treatment modality for colorectal liver metastases. Preoperative conditioning strategies, such as liver venous deprivation, portal vein embolization, and the ALPPS procedure (associating liver partition and portal vein ligation for staged hepatectomy), can facilitate achievement of R0 resection. Liver transplantation within the framework of the LIVER T(W)O HEAL study represents a promising curative treatment option. Perioperative systemic therapy is not standardized and should be determined on an individual basis within an interdisciplinary tumor board. Neoadjuvant therapies aim to reduce metastatic burden and may enable secondary resectability. In cases of unresectable liver metastases, local ablative radiotherapy expands the therapeutic spectrum. Advanced techniques such as stereotactic body radiotherapy and brachytherapy improve local tumor control and contribute to the long-term prognosis and patient quality of life. Overall, treatment strategies should be individualized and based on an interdisciplinary approach. Combinations of surgery, systemic therapy, and local ablative procedures represent promising therapeutic concepts and are the focus of ongoing clinical research.
Involved external institutions
Universitätsklinikum Jena
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Klinikum der Universität München (LMU Klinikum)
Germany (DE)
How to cite
APA:
Schwenk, L., Rauchfuss, F., Caglayan, L., Gkika, E., Corradini, S., Ernst, T., & Settmacher, U. (2025). Multimodal treatment options for oligometastatic colorectal cancer Multimodale Therapiemöglichkeiten beim oligometastasierten kolorektalen Karzinom. Die Onkologie, 31(5), 452-460. https://doi.org/10.1007/s00761-025-01694-4
MLA:
Schwenk, Laura, et al. "Multimodal treatment options for oligometastatic colorectal cancer Multimodale Therapiemöglichkeiten beim oligometastasierten kolorektalen Karzinom." Die Onkologie 31.5 (2025): 452-460.
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