Schuster A, Steines L, Banas B, Bergler T (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 13
Article Number: 7454
Journal Issue: 23
DOI: 10.3390/jcm13237454
Background: Even today, a non-invasive biomarker to identify donors with enhanced risk for renal impairment is missing. Dickkopf 3 (DKK3) can cause tubulointerstitial fibrosis and is associated with rapid eGFR loss. The aim of our work was to analyze whether DKK3 can be used as a non-invasive alert marker for an increased risk of loss of kidney function in living kidney donors (LKDs). Methods: All donors who were examined between July 2022 and June 2023 (n = 117) were included. DKK3 was measured in the urine. The collected patient-related data were compared with parameters before donation. The study cohort was stratified by DKK3 values (≥200). Results: In the follow-up, 89 donors had a DKK3 value < 200 (group 1) and 28 donors had a DKK3 value ≥200 (group 2). During post-donation follow-up, renal function in group 1 was significantly better than that in group 2 (p = 0.01), although no difference in renal function before donation was detected (p = 0.84). Group 2 showed also a greater eGFR loss over time than group 1. Conclusions: LKDs with elevated DKK3 levels in the FU had impaired kidney function without evidence of increased risk factors pre-donation. DKK3 can represent a possible monitoring tool for kidney function in LKDs.
APA:
Schuster, A., Steines, L., Banas, B., & Bergler, T. (2024). Dickkopf 3 as a New Monitoring Tool for Kidney Function After Living Kidney Donation. Journal of Clinical Medicine, 13(23). https://doi.org/10.3390/jcm13237454
MLA:
Schuster, Antonia, et al. "Dickkopf 3 as a New Monitoring Tool for Kidney Function After Living Kidney Donation." Journal of Clinical Medicine 13.23 (2024).
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