Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography
Mohan M, Thoma OM, Sharma S, Sharma G, Waldner M, Singh K
Publication Type: Journal article
Journal
Book Volume: 31
Pages Range: 2477-2486
Journal Issue: 9
DOI: 10.1093/ibd/izaf045
Abstract
Background Inflammatory bowel disease (IBD) is one of the fastest-growing diseases globally. Nearly 5 million people are affected by IBD, with an incremental growth rate of 47.45% between 1990 and 2019. Aim and Methods We aim to provide a noninvasive approach to detecting IBD with an in-house developed 1310 nm endoscopic optical coherence tomography (OCT) system. Mice with acute colitis underwent a longitudinal colon imaging process for real-time and long-run disease progression. The OCT images were processed and segmented using a computer vision image processing-based segmentation algorithm for further thickness mapping and attenuation coefficient calculations. Result An increase in overall colon wall thickness due to inflammation was observed, as well as a reduction in attenuation coefficient due to a change in refractive index. Conclusion Comparable results with white light endoscope and histological examination suggest the clinical potential of the 1310 nm endoscopic OCT system for in vivo assessment of IBD.
Involved external institutions
Germany (DE)How to cite
APA:
Mohan, M., Thoma, O.M., Sharma, S., Sharma, G., Waldner, M., & Singh, K. (2025). Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography. Inflammatory Bowel Diseases, 31(9), 2477-2486. https://doi.org/10.1093/ibd/izaf045
MLA:
Mohan, Muktesh, et al. "Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography." Inflammatory Bowel Diseases 31.9 (2025): 2477-2486.
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