Stelter J, Weiss K, Steinhelfer L, Meineke J, Zhang W, Kainz B, Braren RF, Karampinos DC (2025)
Publication Type: Journal article
Publication year: 2025
DOI: 10.1002/mrm.70040
Purpose: To develop a method for abdominal simultaneous 3D water (Formula presented.) ((Formula presented.)) and (Formula presented.) ((Formula presented.)) mapping with isotropic resolution using a free-breathing Cartesian acquisition with spiral profile ordering (CASPR) at 3 T. Methods: The proposed data acquisition combines a Look-Locker scheme with the modified BIR-4 adiabatic preparation pulse for simultaneous (Formula presented.) and (Formula presented.) mapping. CASPR is employed for efficient and flexible k-space sampling at isotropic resolution during free breathing. The imaging pipeline includes subspace reconstruction, water-fat separation, and (Formula presented.) -specific dictionary matching. The proposed method was validated in a water-fat relaxometry phantom using spin echo-based reference techniques and was compared with MOLLI (Formula presented.) and GRASE (Formula presented.) mapping in 10 volunteers. The method's flexibility was assessed at isotropic resolutions of 2.5, 3, and 3.5 mm, with corresponding scan times of 7:19, 5:23, and 3:52 min. Additionally, the method was applied to 9 oncological patients with abdominal pathologies. Results: Phantom experiments demonstrated good agreement between the proposed method and spin echo-based reference techniques across a wide range of (Formula presented.) and (Formula presented.) values. The volunteer study assessed in vivo quantification performance and demonstrated the flexibility of the proposed method at different spatial resolutions. The 3 mm method was successively performed in patients with abdominal pathologies, whereby lesions with diameters below 1 cm could be assessed. Conclusion: The proposed Look-Locker-based method using CASPR enables efficient, flexible, and simultaneous (Formula presented.) and (Formula presented.) mapping at isotropic resolution in a fixed scan time during free breathing.
APA:
Stelter, J., Weiss, K., Steinhelfer, L., Meineke, J., Zhang, W., Kainz, B.,... Karampinos, D.C. (2025). Abdominal simultaneous 3D water T1 and T2 mapping using a free-breathing Cartesian acquisition with spiral profile ordering. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.70040
MLA:
Stelter, Jonathan, et al. "Abdominal simultaneous 3D water T1 and T2 mapping using a free-breathing Cartesian acquisition with spiral profile ordering." Magnetic Resonance in Medicine (2025).
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