Uncovering the evolving arms race between host immunity and HIV-1
Song YH, Kim H, Baur A, Lee JH (2025)
Publication Type: Journal article, Review article
Publication year: 2025
Journal
Abstract
Despite an effective combination of antiretroviral therapy, HIV persists as a lifelong infection and global health threat. The human host equips restriction factors and interferon (IFN)-stimulated genes that target every step of the viral life cycle. However, HIV-1 has evolved a coordinated immune evasion strategy using a limited set of accessory proteins with distinct antagonistic functions. This functional division of labor allows HIV-1 to disable key immune pathways and ensure persistence. Here, we explore the molecular interplay between host defenses and HIV-1, organizing antiviral factors by viral life cycle stage. We further reframe viral immune evasion as a strategic division of labor among accessory proteins each adapted to target specific host defenses, offering insights for next-generation therapies.
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Korea, Republic of (KR)How to cite
APA:
Song, Y.H., Kim, H., Baur, A., & Lee, J.H. (2025). Uncovering the evolving arms race between host immunity and HIV-1. Trends in immunology. https://doi.org/10.1016/j.it.2025.08.004
MLA:
Song, Young Hwan, et al. "Uncovering the evolving arms race between host immunity and HIV-1." Trends in immunology (2025).
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