Bioactive scaffolds harnessing ionic modifications to promote osteogenesis and angiogenesis in bone regeneration Andamios bioactivos con modificaciones iónicas para promover la osteogénesis y la angiogénesis en la regeneración ósea

Riosalido PM, Arango Ospina M, Velasquez P, Murciano A, Boccaccini AR, De Aza PN (2025)

Publication Language: English

Publication Type: Journal article

Publication year: 2025

Journal

Boletin De La Sociedad Espanola De Ceramica Y Vidrio Consejo Superior de Investigaciones Cientificas

Book Volume: 64

Article Number: 100447

Journal Issue: 4

DOI: 10.1016/j.bsecv.2025.100447

Abstract

This study proposes the modification of multilayer scaffolds based on the SiO2-CaO-P2O5 system by incorporating bioactive ions, such as magnesium or lithium, with the aim of enhancing the cellular processes involved in bone regeneration. Two types of scaffolds, CS04 and CS05, were prepared, varying the amount of MgO (0.38; 0.49% w/w). The prepared scaffolds exhibited an interconnected porous structure, with SiO2, Ca2P2O7 and β-Ca3(PO4)2 as predominant crystalline phases, a compressive strength of 1.8 MPa and a porosity above 75%. Bioactivity tests demonstrated that minor variations in the amount of MgO altered the surface topography and bioactive behaviour, resulting in a lamellar microstructure (CS04) and precipitation of hollow HA spheres (CS05). From a biological point of view, the scaffolds proved to be biocompatible, as were their dissolution products at 10 and 100 mg/mL. Both promoted MC3T3-E1 cell proliferation, calcium deposition and osteoblastic differentiation, as reflected by increased ALP activity. In addition, they induced VEGF release in MC3T3-E1, thereby demonstrating their angiogenic potential. Taken together, these results suggest that the scaffolds possess optimal properties for bone regeneration applications.

Authors with CRIS profile

Marcela Arango Ospina Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Miguel Hernández University of Elche (UMH) / Universidad Miguel Hernández de Elche ES Spain (ES)

How to cite

APA:

Riosalido, P.M., Arango Ospina, M., Velasquez, P., Murciano, A., Boccaccini, A.R., & De Aza, P.N. (2025). Bioactive scaffolds harnessing ionic modifications to promote osteogenesis and angiogenesis in bone regeneration Andamios bioactivos con modificaciones iónicas para promover la osteogénesis y la angiogénesis en la regeneración ósea. Boletin De La Sociedad Espanola De Ceramica Y Vidrio, 64(4). https://doi.org/10.1016/j.bsecv.2025.100447

MLA:

Riosalido, Paula M., et al. "Bioactive scaffolds harnessing ionic modifications to promote osteogenesis and angiogenesis in bone regeneration Andamios bioactivos con modificaciones iónicas para promover la osteogénesis y la angiogénesis en la regeneración ósea." Boletin De La Sociedad Espanola De Ceramica Y Vidrio 64.4 (2025).

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