Histological Characteristics of Patients with Chronic Dacryocystitis, Depending on the Presence of Advanced Dacryolithiasis Histologische Charakteristika von Patienten mit chronischer Dakryozystitis in Abhängigkeit vom Vorhandensein einer fortgeschrittenen Dakryolithiasis
Heichel J, Burghardt ME, Struck HG, Paulsen F, Ali MJ, Viestenz A, Wickenhauser C, Dieβel L (2025)
Publication Type: Journal article
Publication year: 2025
Journal
DOI: 10.1055/a-2635-2419
Abstract
Background Dacryoliths (DL) are found in up to 18% of patients with chronic dacryocystitis (CDC). In particular, the role of neutrophil granulocytes in stone development needs to be clarified. Material and Methods 40 histological specimens from patients with CDC and existing lacrimal sac ectasia were examined. For this purpose, sections of the medial saccus wall were obtained during a transcutaneous dacryocystorhinostomy. Twenty samples showed CDC without DL (group 1), 20 patients showed advanced dacryolithiasis (group 2). The histological criteria (inflammation, fibrosis, lymphocytes, plasma cells, macrophages, neutrophil granulocytes) were scored (0 = not present; 1 = few; 2 = moderate; 3 = numerous/strongly pronounced). Results The gender ratio was balanced (1 : 1; 10 female and 10 male patients per group) and the age difference between groups 1 and 2 was not significant (median 53 vs. 56 y; p = 0.482). The histological parameters showed no significant differences between groups 1 and 2 (inflammation: 39/36, p = 0.292; fibrosis: 21/20, p = 0.385; lymphocytes: 37/32, p = 0.149; plasma cells: 25/24, p = 0.407; macrophages: 19/ 17, p = 0.152; neutrophil granulocytes: 10/13, p = 0.197). Conclusions The histological changes in the medial lacrimal sac wall are not dependent on the presence of dacryoliths. In particular, the presence of neutrophilic granulocytes is not increased in patients with long-standing dacryolithiasis.
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Germany (DE)
India (IN)How to cite
APA:
Heichel, J., Burghardt, M.E., Struck, H.G., Paulsen, F., Ali, M.J., Viestenz, A.,... Dieβel, L. (2025). Histological Characteristics of Patients with Chronic Dacryocystitis, Depending on the Presence of Advanced Dacryolithiasis Histologische Charakteristika von Patienten mit chronischer Dakryozystitis in Abhängigkeit vom Vorhandensein einer fortgeschrittenen Dakryolithiasis. Klinische Monatsblätter für Augenheilkunde. https://doi.org/10.1055/a-2635-2419
MLA:
Heichel, Jens, et al. "Histological Characteristics of Patients with Chronic Dacryocystitis, Depending on the Presence of Advanced Dacryolithiasis Histologische Charakteristika von Patienten mit chronischer Dakryozystitis in Abhängigkeit vom Vorhandensein einer fortgeschrittenen Dakryolithiasis." Klinische Monatsblätter für Augenheilkunde (2025).
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