Role of Transport Proteins for the Renal Handling of L-Arginine and Related Derivatives

Scherpinski L, König J, Maas R (2025)

Publication Type: Journal article, Review article

Publication year: 2025

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 26

Article Number: 7899

Journal Issue: 16

DOI: 10.3390/ijms26167899

Abstract

L-arginine and its derivatives L-homoarginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) show distinct (patho-) physiological properties as well as a differential renal handling. L-arginine and L-homoarginine have a lower renal clearance and are largely retained (i.e., reabsorbed) as compared to ADMA and SDMA, which are relatively enriched in the urine and excreted. To obtain a more complete picture of what is known regarding transport proteins involved in renal reabsorption and secretion of these substances, a comprehensive literature review and search of cell-specific gene expression databases were performed. Five transport proteins known to transport L-arginine and its derivatives were included, and the data available regarding their tubular expression pattern and their transport characteristics, as well as experimental and clinical data regarding their possible impact on the renal handling of L-arginine and its derivatives, are presented and discussed in a structured narrative review. Based on their transport properties and links to clinical phenotypes, b^0,+AT-rBAT and y⁺LAT1-4F2hc were identified as the most promising candidates to explain a significant part of the observed differential renal handling. This also makes them promising candidates for further investigations as mediators of possible adverse and beneficial drug effects involving L-arginine, L-homoarginine, ADMA, and SDMA.

Authors with CRIS profile

Lorenz Scherpinski Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Jörg König Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Renke Maas Professur für Arzneimitteltherapiesicherheit und Klinische Pharmakologie

How to cite

APA:

Scherpinski, L., König, J., & Maas, R. (2025). Role of Transport Proteins for the Renal Handling of L-Arginine and Related Derivatives. International Journal of Molecular Sciences, 26(16). https://doi.org/10.3390/ijms26167899

MLA:

Scherpinski, Lorenz, Jörg König, and Renke Maas. "Role of Transport Proteins for the Renal Handling of L-Arginine and Related Derivatives." International Journal of Molecular Sciences 26.16 (2025).

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