Consensus on acromegaly therapeutic outcomes: an update

Melmed S, di Filippo L, Fleseriu M, Mercado M, Karavitaki N, Gurnell M, Salvatori R, Tsagarakis S, Losa M, Maffei P, Pereira AM, Geer EB, Katznelson L, van der Lely AJ, Bollerslev J, Esposito D, Webb SM, Zatelli MC, Valassi E, Neggers S, Chanson P, Ho KK, Ioachimescu AG, Biller BM, Samson SL, Kaiser UB, Schilbach K, Luque RM, Casanueva FF, Shimon I, Boguszewski CL, Biermasz N, Colao A, Pirchio R, Lamberts SW, Kadioglu P, Buchfelder M, Frara S, Chiloiro S, Petersenn S, Gadelha MR, Puig-Domingo M, Luger A, Brue T, Beckers A, Ferone D, Clemmons DR, Greenman Y, Marazuela M, Mortini P, Strasburger CJ, Giustina A (2025)

Publication Type: Journal article

Publication year: 2025

Journal

DOI: 10.1038/s41574-025-01148-2

Abstract

The 15th Acromegaly Consensus Conference in September 2023 updated recommendations on therapeutic outcomes for acromegaly. Since the publication of medical management guidelines in 2018, new pharmacological agents and new treatment approaches have been developed. Fifty-two experts in the management of acromegaly reviewed the current literature and assessed changes in drug approvals, clinical practice standards and management. Current outcome goals were considered, with a focus on the effect of current and emerging somatostatin receptor ligands, the growth hormone receptor antagonist pegvisomant and the dopamine agonist cabergoline on biochemical control, clinical control, adenoma mass and surgical outcomes. Participants assessed factors that determine pharmacological choices, as well as the proposed use of each agent. Here, we present consensus recommendations highlighting how an evidence-based acromegaly management algorithm could be optimized in clinical practice.

Authors with CRIS profile

Involved external institutions

Cedars-Sinai Medical Center United States (USA) (US) Università Vita-Salute San Raffaele (UniSR) Italy (IT) Oregon Health and Science University (OSHU) United States (USA) (US) Centro Medico Nacional Siglo XXI Mexico (MX) Queen Elizabeth Hospital Birmingham United Kingdom (GB) University of Cambridge United Kingdom (GB) Johns Hopkins Hospital United States (USA) (US) Evangelismos Medical Center Greece (GR) Università degli Studi di Napoli Federico II Italy (IT) University of Padua / Universita degli Studi di Padova Italy (IT) University of North Carolina at Chapel Hill United States (USA) (US) Tel Aviv University Israel (IL) Instituto de Investigación Sanitaria Princesa Spain (ES) Charité - Universitätsmedizin Berlin Germany (DE) Memorial Sloan Kettering Cancer Center United States (USA) (US) Stanford University United States (USA) (US) University of Cordoba / Universidad de Córdoba (UCO) Spain (ES) University of Santiago de Compostela / Universidad de Santiago de Compostela (USC) Spain (ES) Medizinische Universität Wien Austria (AT) Aix-Marseille University / Aix-Marseille Université France (FR) University of Amsterdam Netherlands (NL) Erasmus University Medical Center (MC) Netherlands (NL) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset Sweden (SE) Sant Pau Institute for Biomedical Research (IIBSP) / Institut de Recerca de L’hospital de La Santa Creu i de Sant Pau Spain (ES) Università degli Studi di Ferrara Italy (IT) Health Sciences Research Institute of the “Germans Trias i Pujol” Foundation (IGTP) Spain (ES) Université Paris-Saclay France (FR) University of New South Wales (UNSW) Australia (AU) Medical College of Wisconsin (MCW) United States (USA) (US) Massachusetts General Hospital United States (USA) (US) Mayo Clinic Hospital United States (USA) (US) Harvard University United States (USA) (US) Klinikum der Universität München Germany (DE) Rabin Medical Center / מרכז רפואי רבין‎‎ Israel (IL) Universidade Federal do Paraná (UFPR) Brazil (BR) Leiden University Medical Center Netherlands (NL) Istanbul University Cerrahpaşa / İstanbul Üniversitesi Cerrahpaşa (IUC) Turkey (TR) Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore Italy (IT) ENDOC Praxis für Endokrinologie, Andrologie und medikamentöse Tumortherapie Germany (DE) Universidade Federal do Rio de Janeiro (UFRJ) / Federal University of Rio de Janeiro Brazil (BR) University of Liège (ULg) / Université de Liège Belgium (BE) Ospedale Policlinico San Martino Italy (IT)

How to cite

APA:

Melmed, S., di Filippo, L., Fleseriu, M., Mercado, M., Karavitaki, N., Gurnell, M.,... Giustina, A. (2025). Consensus on acromegaly therapeutic outcomes: an update. Nature Reviews Endocrinology. https://doi.org/10.1038/s41574-025-01148-2

MLA:

Melmed, Shlomo, et al. "Consensus on acromegaly therapeutic outcomes: an update." Nature Reviews Endocrinology (2025).

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