Tackling gender in progressive supranuclear palsy: Male patients present more apathy

Ye L, Greten S, Wilkens I, Wegner F, Krey L, Höllerhage M, Pötter-Nerger M, Zeitzschel M, Hagena K, Kassubek J, Süß P, Winkler J, Berg D, Paschen S, Tönges L, Gruber D, Gandor F, Jost WH, Kühn AA, Claus I, Warnecke T, Pedrosa DJ, Eggers C, Trenkwalder C, Classen J, Schwarz J, Schnitzler A, Höglinger GU, Klietz M (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Book Volume: 15

Pages Range: 1024-1028

Journal Issue: 5

DOI: 10.1177/1877718X251343094

Abstract

Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients.

Authors with CRIS profile

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universität Ulm Germany (DE) Christian-Albrechts-Universität zu Kiel Germany (DE) Katholisches Klinikum Bochum (St. Josef- und St. Elisabeth-Hospital gGmbH) Germany (DE) Neurologisches Fachkrankenhaus für Bewegungsstörungen / Parkinson Germany (DE) Parkinson-Klinik Ortenau Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universitätsklinikum Münster Germany (DE) Klinikum Osnabrück Germany (DE) Universitätsklinikum Gießen und Marburg (UKGM) Germany (DE) Knappschaftskrankenhaus Bottrop Germany (DE) Paracelsus-Elena-Klinik Kassel Germany (DE) Universität Leipzig Germany (DE) Heinrich-Heine-Universität Düsseldorf Germany (DE) Klinikum der Universität München Germany (DE)

How to cite

APA:

Ye, L., Greten, S., Wilkens, I., Wegner, F., Krey, L., Höllerhage, M.,... Klietz, M. (2025). Tackling gender in progressive supranuclear palsy: Male patients present more apathy. Journal of Parkinson's Disease, 15(5), 1024-1028. https://doi.org/10.1177/1877718X251343094

MLA:

Ye, Lan, et al. "Tackling gender in progressive supranuclear palsy: Male patients present more apathy." Journal of Parkinson's Disease 15.5 (2025): 1024-1028.

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