Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study
Ji J, Shi X, Tang E, Zheng J, Liang L (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 24
Article Number: e70398
Journal Issue: 8
DOI: 10.1111/jocd.70398
Abstract
Background: Previous studies reported that patients with keloid, acne, or hypertrophic scar (HS) had lower serum vitamin D levels compared to healthy controls. Whereas, these works failed to verify their causal relationships. Hence, we performed a Mendelian randomization (MR) aimed to investigate the causal relationship between vitamin D and keloid, acne, or HS. Methods: Utilizing summary datasets from genome-wide association studies, we conducted a two-sample MR analysis to explore the causal relationship between vitamin D and keloid, acne, or HS. The inverse-variance weighted MR approach served as the primary analysis, with additional support from various sensitivity methods, including MR-Egger, weighted median, simple mode, weighted mode, and MR-PRESSO, to enhance the reliability of our findings. Results: From our MR analyses, no causal relationships were found between vitamin D level and keloid (OR: 1.15, 95% CI: 0.853–1.16, p = 0.36), acne (OR: 0.94, 95% CI: 0.66–1.30, p = 0.65) or HS (OR: 1.20, 95% CI 0.79–1.82, p = 0.40) formation. After eliminating outliers through MR-PRESSO, no significant associations were found between serum vitamin D level and keloid, acne, as well as HS. Conclusion: Our findings, backed by rigorous IV selection and consistent outcomes across various MR approaches, suggest no causal link between serum 25(OH)D levels and keloid, acne, or HS. While vitamin D is involved in wound healing, its connection to these conditions may not be straightforward, emphasizing the need for further research.
Authors with CRIS profile
Involved external institutions
Aerospace Center Hospital
China (CN)
Peking Union Medical College Hospital (PUMCH) / Beijing Xiehe Hospital
China (CN)
The Hong Kong University of Science and Technology (Guangzhou) / 香港科技大学(广州) (HKUST (GZ))
China (CN)
China (CN)
Peking Union Medical College Hospital (PUMCH) / Beijing Xiehe Hospital
China (CN)
The Hong Kong University of Science and Technology (Guangzhou) / 香港科技大学(广州) (HKUST (GZ))
China (CN)
How to cite
APA:
Ji, J., Shi, X., Tang, E., Zheng, J., & Liang, L. (2025). Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study. Journal of Cosmetic Dermatology, 24(8). https://doi.org/10.1111/jocd.70398
MLA:
Ji, Jiaqi, et al. "Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study." Journal of Cosmetic Dermatology 24.8 (2025).
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