Silver-Loaded Titania-Based Metal–Organic Frameworks as a Platform for Silver Ion Release for Antibacterial Applications

Mazare AV, Goldmann W, Kocak E, Osuagwu B, Qin S, Cao R, Schmuki P (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Nano Letters American Chemical Society

Book Volume: 25

Pages Range: 12547-12553

Journal Issue: 33

DOI: 10.1021/acs.nanolett.5c02681

Abstract

Conventional Ag-decorated TiO2coatings suffer from low adsorption capacity and burst release kinetics, limiting long-term antibacterial efficacy and risking cytotoxicity. An entirely different payload release approach can be based on metal–organic frameworks (MOFs), which offer tunable porosity, high surface area, and internal diffusion channels. Here, we report a thermally stabilized Ti-based MOF [NH2-MIL-125(Ti)] functionalized with Ag+via reactive deposition, enabling high Ag loading (∼14.7 wt %) and sustained release. Annealing at 250 °C enhances aqueous stability, allowing diffusion-governed Ag+delivery over >48 h, with 77% of the Ag still present in the MOF after a 24 h release. The system exhibits dose-dependent antibacterial activity in powders and comparable efficacy in coatings, with a more gradual release profile. This scalable platform is promising for long-acting coatings, wound interfaces, and implantable materials.

Authors with CRIS profile

Anca Valentina Mazare Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) (LKO) Wolfgang Goldmann Lehrstuhl für Biophysik Emeka Benedict Osuagwu Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) (LKO) Shanshan Qin Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) (LKO) Patrik Schmuki Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) (LKO)

Involved external institutions

Donghua University / 东华大学 CN China (CN)

How to cite

APA:

Mazare, A.V., Goldmann, W., Kocak, E., Osuagwu, B., Qin, S., Cao, R., & Schmuki, P. (2025). Silver-Loaded Titania-Based Metal–Organic Frameworks as a Platform for Silver Ion Release for Antibacterial Applications. Nano Letters, 25(33), 12547-12553. https://doi.org/10.1021/acs.nanolett.5c02681

MLA:

Mazare, Anca Valentina, et al. "Silver-Loaded Titania-Based Metal–Organic Frameworks as a Platform for Silver Ion Release for Antibacterial Applications." Nano Letters 25.33 (2025): 12547-12553.

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