Nanofibrous dressings incorporating a synergistic antibacterial-anti-inflammatory effect for infected wound healing
Xu W, Xu T, Yu L, Ning X, Zhang C, Yi B, Dai W, Zhu Z, Zhao H (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 34
Article Number: 102155
DOI: 10.1016/j.mtbio.2025.102155
Abstract
Bacterial infections and chronic inflammation disrupt wound immune homeostasis and impair healing progression. Herein, we report a novel nanofibrous dressings that exhibits a synergistic antibacterial-anti-inflammatory effect through the integration of the physical barrier properties of electrospun nanofibers, the antimicrobial activity of biomacromolecule polylysine (PLys), and the anti-inflammatory and antioxidant effects of natural macromolecule tannic acid (TA). Using poly(L-lactide-co-ε-caprolactone) (PLCL) as the base biomaterial, sequential surface modification with TA and PLys enhanced wettability and introduced a positive surface charge, yielding a dressing with exceptional cytocompatibility and potent antimicrobial activity against Staphylococcus aureus. In vitro studies revealed that the PLys-grafted, mussel-inspired nanofibers (PLys@TA@PLCL) modulated the wound microenvironment by suppressing fibroblast-to-myofibroblast differentiation, mitigating pro-inflammatory responses, and accelerating extracellular matrix (ECM) deposition and remodeling. In vivo evaluations demonstrated that PLys@TA@PLCL nanofibers effectively reduced bacterial burden and prevented yellow scab formation, while accelerating healing of infected wounds. Notably, these dressings exhibited robust anti-inflammatory activity during early stages of repair and promoted near-complete wound closure by 2 weeks, accompanied by enhanced collagen synthesis, skin regeneration, and hair follicle neogenesis. Collectively, these findings highlight the therapeutic potential of PLys@TA-modified nanofibrous dressings for managing chronic, full-thickness wounds.
Involved external institutions
China (CN)How to cite
APA:
Xu, W., Xu, T., Yu, L., Ning, X., Zhang, C., Yi, B.,... Zhao, H. (2025). Nanofibrous dressings incorporating a synergistic antibacterial-anti-inflammatory effect for infected wound healing. Materials Today Bio, 34. https://doi.org/10.1016/j.mtbio.2025.102155
MLA:
Xu, Wei, et al. "Nanofibrous dressings incorporating a synergistic antibacterial-anti-inflammatory effect for infected wound healing." Materials Today Bio 34 (2025).
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