Role of Chimeric Antigen Receptor–Expressing Cell Therapy in Immune-Mediated Kidney Diseases: A Review
Peng J, Zhang Y, Wang J, Zhang H, Schett G (2025)
Publication Type: Journal article, Review article
Publication year: 2025
Journal
DOI: 10.1053/j.ajkd.2025.04.012
Abstract
Immune-mediated kidney diseases are characterized by an adaptive immune response directed against various self-antigens. B cells, as progenitors of autoantibody-producing plasma cells and as antigen-presenting cells, play a crucial role in the pathogenesis of these diseases. Despite significant advancements in B-cell-targeting therapies, relapses are common among patients. Evidence of insufficient B-cell depletion by monoclonal antibodies such as rituximab, and the inability to deplete plasma cells, suggests that a more robust and complete B-cell depletion may be necessary for immune-mediated kidney diseases. Chimeric antigen receptor (CAR)-expressing cell therapy has emerged as a promising option. In this approach, immune cells like T cells are genetically engineered to recognize specific markers on B cells. By leveraging T cells’ natural ability to infiltrate tissues and their high-affinity target binding, this method enables a deeper clearance of B cells than is usually observed with B-cell-depleting monoclonal antibodies. This review explores the potential of using B-cell-depleting CAR-expressing cell therapy in the treatment of immune-mediated kidney diseases.
Authors with CRIS profile
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China (CN)How to cite
APA:
Peng, J., Zhang, Y., Wang, J., Zhang, H., & Schett, G. (2025). Role of Chimeric Antigen Receptor–Expressing Cell Therapy in Immune-Mediated Kidney Diseases: A Review. American Journal of Kidney Diseases. https://doi.org/10.1053/j.ajkd.2025.04.012
MLA:
Peng, Jiawen, et al. "Role of Chimeric Antigen Receptor–Expressing Cell Therapy in Immune-Mediated Kidney Diseases: A Review." American Journal of Kidney Diseases (2025).
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