Longitudinal Course and Baseline Predictors of Trajectories of Clinician-assessed Adherence to Immunosuppressant Medication in Patients after Kidney Transplantation: A KTx360° Substudy

De Zwaan M, Nöhre M, Klewitz F, Bauer-Hohmann M, Kuczyk C, Erim Y, Schiffer L, Meier D, Wolff JK, Tegtbur U, Pape L, Schiffer M (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Transplantation Direct Lippincott, Williams & Wilkins

Book Volume: 11

Pages Range: e1813-

Journal Issue: 8

DOI: 10.1097/TXD.0000000000001813

Abstract

Background. Optimal and maintained adherence to immunosuppressive medication is essential to kidney graft success. Methods. We analyzed the longitudinal course of immunosuppressant adherence as measured with the Basel Assessment of Adherence to Immunosuppressive Medication Scale interview for up to 3-y duration of the Kidney Transplantation 360° study. Additionally, we examined putative baseline predictors of adherence trajectories. During the investigation period, patients participated in a multidisciplinary aftercare program consisting of case management, psychosocial and exercise assessments and interventions, including telemedicine support. Results. The analysis sample with at least 1 valid information on the Basel Assessment of Adherence to Immunosuppressive Medication Scale consisted of 838 adult patients (41.3% women) aged 52.3 y (SD 13.5). Adherence to immunosuppressants improved significantly during the Kidney Transplantation 360° aftercare program; however, at each assessment point, 17%-25% of the patients still reported suboptimal adherence. Baseline predictors for a better improvement of adherence were younger age, male sex, and a longer duration since transplantation. Those variables were associated with a lower adherence at baseline, and we detected a "catch-up effect"over time, which might have been supported by the comprehensive aftercare program. Conclusions. We believe that our aftercare program has supported the "catch-up effect"in adherence in younger male patients with a longer time after transplantation. However, the lack of a control group limits causal interpretations.

Authors with CRIS profile

Yesim Erim Professur für Psychosomatik und Psychotherapie Mario Schiffer Lehrstuhl für Innere Medizin IV

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) IGES Institut DE Germany (DE) Universitätsklinikum Essen DE Germany (DE)

How to cite

APA:

De Zwaan, M., Nöhre, M., Klewitz, F., Bauer-Hohmann, M., Kuczyk, C., Erim, Y.,... Schiffer, M. (2025). Longitudinal Course and Baseline Predictors of Trajectories of Clinician-assessed Adherence to Immunosuppressant Medication in Patients after Kidney Transplantation: A KTx360° Substudy. Transplantation Direct, 11(8), e1813-. https://doi.org/10.1097/TXD.0000000000001813

MLA:

De Zwaan, Martina, et al. "Longitudinal Course and Baseline Predictors of Trajectories of Clinician-assessed Adherence to Immunosuppressant Medication in Patients after Kidney Transplantation: A KTx360° Substudy." Transplantation Direct 11.8 (2025): e1813-.

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